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gpt2 glutamic pyruvate transaminase (alanine aminotransferase) 2 [ Danio rerio (zebrafish) ]

Gene ID: 799963, updated on 4-Jan-2025

Summary

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Official Symbol
gpt2provided by ZNC
Official Full Name
glutamic pyruvate transaminase (alanine aminotransferase) 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030729-8
See related
Ensembl:ENSDARG00000012199 AllianceGenome:ZFIN:ZDB-GENE-030729-8
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb580; im:7150662; zgc:165657
Summary
Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-alanine catabolic process. Predicted to act upstream of or within biosynthetic process. Is expressed in several structures, including axial chorda mesoderm; axis; immature eye; musculature system; and nervous system. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See gpt2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (41887378..41900076)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (41607710..41619117)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene origin recognition complex, subunit 6 Neighboring gene myosin light chain kinase 3 Neighboring gene zgc:92818 Neighboring gene DnaJ heat shock protein family (Hsp40) member A2a Neighboring gene afadin- and alpha-actinin-binding protein-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Bioenergetic dysfunction in a zebrafish model of acute hyperammonemic decompensation. Zielonka M, et al. Exp Neurol, 2019 Apr. PMID 30653968
  2. Knock-Down of Histidyl-tRNA Synthetase Causes Cell Cycle Arrest and Apoptosis of Neuronal Progenitor Cells in vivo. Waldron A, et al. Front Cell Dev Biol, 2019. PMID 31134197, Free PMC Article
  3. Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Mirando AC, et al. Sci Rep, 2015 Aug 14. PMID 26271225, Free PMC Article
  4. Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio). Zhu QS, et al. Nutr Metab (Lond), 2020. PMID 32818036, Free PMC Article
  5. Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase. Zielonka M, et al. PLoS One, 2018. PMID 30199544, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC165657

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
alanine aminotransferase 2
NP_001092227.2
XP_068078523.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098757.2 → NP_001092227.2  alanine aminotransferase 2

    Status: VALIDATED

    Source sequence(s)
    CU672230
    UniProtKB/TrEMBL
    A0A8M1NDP9
    Related
    ENSDARP00000104098.3, ENSDART00000115090.7
    Conserved Domains (2) summary
    cd00609
    Location:83 → 471
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PTZ00377
    Location:2 → 481
    PTZ00377; alanine aminotransferase; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    41887378..41900076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222422.1 → XP_068078523.1  alanine aminotransferase 2 isoform X1

Nucleotide Protein
Heading Accession and Version

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