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Kcnip4 Kv channel interacting protein 4 [ Mus musculus (house mouse) ]

Gene ID: 80334, updated on 27-Nov-2024

Summary

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Official Symbol
Kcnip4provided by MGI
Official Full Name
Kv channel interacting protein 4provided by MGI
Primary source
MGI:MGI:1933131
See related
Ensembl:ENSMUSG00000029088 AllianceGenome:MGI:1933131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Calp; KChIP4; Calp250; KChIP4a
Summary
Enables calcium ion binding activity and potassium channel regulator activity. Involved in regulation of potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. Is expressed in brain; dorsal root ganglion; meninges; retina; and spinal cord. Orthologous to human KCNIP4 (potassium voltage-gated channel interacting protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 12.2), cortex adult (RPKM 6.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnip4 in Genome Data Viewer
Location:
5 B3; 5 26.26 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (48546845..49682464, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (48389503..49525122, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene slit guidance ligand 2 Neighboring gene microRNA 218-1 Neighboring gene STARR-seq mESC enhancer starr_13026 Neighboring gene STARR-positive B cell enhancer ABC_E4755 Neighboring gene RIKEN cDNA 5730480H06 gene Neighboring gene PARK2 co-regulated-like Neighboring gene STARR-seq mESC enhancer starr_13027 Neighboring gene predicted gene, 52772 Neighboring gene STARR-seq mESC enhancer starr_13028 Neighboring gene STARR-seq mESC enhancer starr_13030 Neighboring gene STARR-seq mESC enhancer starr_13031 Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene Neighboring gene predicted gene 10048 Neighboring gene STARR-seq mESC enhancer starr_13032 Neighboring gene STARR-seq mESC enhancer starr_13033 Neighboring gene cytochrome c-like Neighboring gene STARR-seq mESC enhancer starr_13034 Neighboring gene predicted gene, 54297 Neighboring gene NSFL1 (p97) cofactor (p47) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes. Schwenk J, et al. J Biol Chem, 2008 Jul 4. PMID 18458082, Free PMC Article
  2. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. Himes BE, et al. PLoS One, 2013. PMID 23457522, Free PMC Article
  3. Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a. Liang P, et al. Biophys J, 2010 Jun 16. PMID 20550899, Free PMC Article
  4. Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation. Liang P, et al. J Biol Chem, 2009 Feb 20. PMID 19109250
  5. Differential distribution of KChIPs mRNAs in adult mouse brain. Xiong H, et al. Brain Res Mol Brain Res, 2004 Sep 28. PMID 15363885

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse.
    Title: Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.
  2. KChIP4a functions to promote tetrameric assembly and enhance surface expression of Kv4 channels.
    Title: Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a.
  3. These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a.
    Title: KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.
  4. N-terminal binding of Kv4.3 to the core of KChIP4a mobilizes the KChIP4a N terminus, which serves as the slow inactivation gate.
    Title: Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation.
  5. Surface expression of Kv4 complexes may thus be controlled by an auto-inhibitory domain in the KChIP subunit.
    Title: NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes.
  6. KChIP4 was highly expressed by neurons in layers II-IV of cortex and in hippocampus, thalamus and the Purkinje cell layer of the cerebellum.
    Title: Differential distribution of KChIPs mRNAs in adult mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Kv channel-interacting protein 4
Names
A-type potassium channel modulatory protein 4
calsenilin-like protein
potassium channel interacting protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199242.1 → NP_001186171.1  Kv channel-interacting protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1)
    Source sequence(s)
    AK148685, BC051130
    Consensus CDS
    CCDS57342.1
    UniProtKB/Swiss-Prot
    Q6DTJ3, Q6PHZ8, Q8CAD0, Q8R4I2, Q9EQ01
    UniProtKB/TrEMBL
    Q3YAA8
    Related
    ENSMUSP00000084656.5, ENSMUST00000087395.11
    Conserved Domains (1) summary
    COG5126
    Location:80 → 239
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_001199243.1 → NP_001186172.1  Kv channel-interacting protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame 5' exon, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AK148685, BC051130, DQ148502
    Consensus CDS
    CCDS57341.1
    UniProtKB/TrEMBL
    Q3YAA7
    Related
    ENSMUSP00000135071.3, ENSMUST00000176191.8
    Conserved Domains (1) summary
    COG5126
    Location:46 → 205
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. NM_001199244.1 → NP_001186173.1  Kv channel-interacting protein 4 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has a distinct 5' end, compared to variant (1), which results in an isoform (5) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK148685
    Consensus CDS
    CCDS57340.1
    UniProtKB/TrEMBL
    Q3UFC0
    Related
    ENSMUSP00000135799.2, ENSMUST00000175660.5
    Conserved Domains (1) summary
    COG5126
    Location:55 → 214
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  4. NM_001199245.1 → NP_001186174.1  Kv channel-interacting protein 4 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has a distinct 5' end, compared to variant (1), which results in an isoform (6) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK148685, DQ148504
    Consensus CDS
    CCDS57339.1
    UniProtKB/TrEMBL
    Q3YAA5
    Related
    ENSMUSP00000131276.2, ENSMUST00000166924.8
    Conserved Domains (1) summary
    COG5126
    Location:63 → 222
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  5. NM_030265.3 → NP_084541.3  Kv channel-interacting protein 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has a distinct 5' end, compared to variant (1), which results in an isoform (4) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK039048, AK148685
    Consensus CDS
    CCDS39084.1
    UniProtKB/TrEMBL
    Q3YAA6
    Related
    ENSMUSP00000134758.2, ENSMUST00000176978.8
    Conserved Domains (1) summary
    COG5126
    Location:59 → 218
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    48546845..49682464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165622.1 → XP_036021515.1  Kv channel-interacting protein 4 isoform X5

    Conserved Domains (1) summary
    COG5126
    Location:29 → 188
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. XM_036165624.1 → XP_036021517.1  Kv channel-interacting protein 4 isoform X7

    UniProtKB/TrEMBL
    Q3V060
    Conserved Domains (1) summary
    COG5126
    Location:18 → 177
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. XM_030254922.2 → XP_030110782.1  Kv channel-interacting protein 4 isoform X7

    UniProtKB/TrEMBL
    Q3V060
    Conserved Domains (1) summary
    COG5126
    Location:18 → 177
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  4. XM_030254920.1 → XP_030110780.1  Kv channel-interacting protein 4 isoform X4

    Conserved Domains (1) summary
    COG5126
    Location:46 → 152
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  5. XM_030254917.1 → XP_030110777.1  Kv channel-interacting protein 4 isoform X1

    Conserved Domains (1) summary
    COG5126
    Location:80 → 186
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  6. XM_030254919.1 → XP_030110779.1  Kv channel-interacting protein 4 isoform X3

    Conserved Domains (1) summary
    COG5126
    Location:59 → 165
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  7. XM_036165623.1 → XP_036021516.1  Kv channel-interacting protein 4 isoform X6

    Conserved Domains (1) summary
    COG5126
    Location:18 → 124
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  8. XM_030254921.1 → XP_030110781.1  Kv channel-interacting protein 4 isoform X6

    Conserved Domains (1) summary
    COG5126
    Location:18 → 124
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  9. XM_030254918.1 → XP_030110778.1  Kv channel-interacting protein 4 isoform X2

    Conserved Domains (1) summary
    COG5126
    Location:63 → 169
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PHZ8.1 GenPept UniProtKB/Swiss-Prot:Q6PHZ8

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