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TMEM177 transmembrane protein 177 [ Homo sapiens (human) ]

Gene ID: 80775, updated on 27-Nov-2024

Summary

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Official Symbol
TMEM177provided by HGNC
Official Full Name
transmembrane protein 177provided by HGNC
Primary source
HGNC:HGNC:28143
See related
Ensembl:ENSG00000144120 MIM:620752; AllianceGenome:HGNC:28143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum (RPKM 5.2), kidney (RPKM 5.0) and 25 other tissues See more
Orthologs
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Genomic context

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See TMEM177 in Genome Data Viewer
Location:
2q14.2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (119679201..119723618)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (120112838..120157662)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120436777..120481194)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120238515-120239026 Neighboring gene VISTA enhancer hs1941 Neighboring gene secretin receptor Neighboring gene SCTR antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11908 Neighboring gene cilia and flagella associated protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11909 Neighboring gene MPRA-validated peak3833 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11911 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:120457784-120458983 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120459450-120460055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120460663-120461267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120472887-120473388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120473389-120473888 Neighboring gene uncharacterized LOC101927764 Neighboring gene ribosomal protein L17 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11912 Neighboring gene Sharpr-MPRA regulatory region 5959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:120517730-120518354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16454 Neighboring gene protein tyrosine phosphatase non-receptor type 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11914 Neighboring gene MPRA-validated peak3834 silencer Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein L27 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis. Lorenzi I, et al. Biochim Biophys Acta Mol Cell Res, 2018 Feb. PMID 29154948, Free PMC Article
  2. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Luo J, et al. Cell, 2009 May 29. PMID 19490893, Free PMC Article
  3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Floyd BJ, et al. Mol Cell, 2016 Aug 18. PMID 27499296, Free PMC Article
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
  5. Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding. Tran DT, et al. Diabetes, 2020 Aug. PMID 32457219, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32751, MGC10993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex II assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion HTP PubMed 

General protein information

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Preferred Names
transmembrane protein 177

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105198.2 → NP_001098668.1  transmembrane protein 177

    See identical proteins and their annotated locations for NP_001098668.1

    Status: VALIDATED

    Source sequence(s)
    AC069154
    Consensus CDS
    CCDS2128.1
    UniProtKB/Swiss-Prot
    Q53S58, Q9BT20
    UniProtKB/TrEMBL
    B3KUD0
    Related
    ENSP00000402661.1, ENST00000424086.5
    Conserved Domains (1) summary
    cl02872
    Location:221 → 264
    DHQ_Fe-ADH; Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH)

  2. NM_001105199.2 → NP_001098669.1  transmembrane protein 177

    See identical proteins and their annotated locations for NP_001098669.1

    Status: VALIDATED

    Source sequence(s)
    AC069154
    Consensus CDS
    CCDS2128.1
    UniProtKB/Swiss-Prot
    Q53S58, Q9BT20
    UniProtKB/TrEMBL
    B3KUD0
    Related
    ENSP00000385966.1, ENST00000401466.5
    Conserved Domains (1) summary
    cl02872
    Location:221 → 264
    DHQ_Fe-ADH; Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH)

  3. NM_030577.3 → NP_085054.2  transmembrane protein 177

    See identical proteins and their annotated locations for NP_085054.2

    Status: VALIDATED

    Source sequence(s)
    AC069154
    Consensus CDS
    CCDS2128.1
    UniProtKB/Swiss-Prot
    Q53S58, Q9BT20
    UniProtKB/TrEMBL
    B3KUD0
    Related
    ENSP00000272521.6, ENST00000272521.7
    Conserved Domains (1) summary
    cl02872
    Location:221 → 264
    DHQ_Fe-ADH; Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH)

RNA

  1. NR_148341.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC069154, AK057313, HY262393

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    119679201..119723618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007082535.1 RNA Sequence

  2. XR_002959349.2 RNA Sequence

  3. XR_007082536.1 RNA Sequence

  4. XR_007082532.1 RNA Sequence

  5. XR_007082531.1 RNA Sequence

  6. XR_002959346.2 RNA Sequence

  7. XR_007082533.1 RNA Sequence

  8. XR_002959347.2 RNA Sequence

  9. XR_007082534.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    120112838..120157662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008486537.1 RNA Sequence

  2. XR_008486538.1 RNA Sequence

  3. XR_008486536.1 RNA Sequence

  4. XR_008486539.1 RNA Sequence

  5. XR_008486531.1 RNA Sequence

  6. XR_008486530.1 RNA Sequence

  7. XR_008486533.1 RNA Sequence

  8. XR_008486532.1 RNA Sequence

  9. XR_008486534.1 RNA Sequence

  10. XR_008486535.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q53S58.1 GenPept UniProtKB/Swiss-Prot:Q53S58

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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