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Tmprss5 transmembrane protease, serine 5 (spinesin) [ Mus musculus (house mouse) ]

Gene ID: 80893, updated on 27-Nov-2024

Summary

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Official Symbol
Tmprss5provided by MGI
Official Full Name
transmembrane protease, serine 5 (spinesin)provided by MGI
Primary source
MGI:MGI:1933407
See related
Ensembl:ENSMUSG00000032268 AllianceGenome:MGI:1933407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
spinesin
Summary
Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in neuronal cell body. Orthologous to human TMPRSS5 (transmembrane serine protease 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 2.0), stomach adult (RPKM 1.3) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Tmprss5 in Genome Data Viewer
Location:
9 A5.3; 9 26.59 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (49013994..49028891)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (49079274..49117591)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24085 Neighboring gene claudin 25 Neighboring gene zw10 kinetochore protein Neighboring gene STARR-seq mESC enhancer starr_24086 Neighboring gene STARR-seq mESC enhancer starr_24087 Neighboring gene STARR-seq mESC enhancer starr_24088 Neighboring gene STARR-seq mESC enhancer starr_24089 Neighboring gene predicted gene 4894 Neighboring gene STARR-seq mESC enhancer starr_24090 Neighboring gene dopamine receptor D2 Neighboring gene STARR-seq mESC enhancer starr_24091 Neighboring gene predicted gene, 46111

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5. Watanabe Y, et al. Biochem Biophys Res Commun, 2004 Nov 5. PMID 15465023
  2. cAMP-dependent regulation of spinesin/TMPRSS5 gene expression in astrocytes. Yamaguchi T, et al. J Neurosci Res, 2008 Feb 15. PMID 17918741
  3. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Guipponi M, et al. Hum Mutat, 2008 Jan. PMID 17918732
  4. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article
  5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protease serine 5
NP_001346389.1
NP_001408238.1
NP_109634.2
XP_006510772.1
XP_036011307.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359460.2 → NP_001346389.1  transmembrane protease serine 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159825, AC160137
    Consensus CDS
    CCDS90560.1
    UniProtKB/Swiss-Prot
    E9Q2A5, Q9ER02, Q9ER03, Q9ER04
    UniProtKB/TrEMBL
    Q8CDR0
    Related
    ENSMUSP00000132181.2, ENSMUST00000165088.8
    Conserved Domains (2) summary
    smart00020
    Location:217 → 448
    Tryp_SPc; Trypsin-like serine protease
    pfam15494
    Location:116 → 213
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. NM_001421309.1 → NP_001408238.1  transmembrane protease serine 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159825, AC160137

  3. NM_030709.3 → NP_109634.2  transmembrane protease serine 5 isoform 2

    See identical proteins and their annotated locations for NP_109634.2

    Status: VALIDATED

    Source sequence(s)
    AC159825, AC160137
    Consensus CDS
    CCDS52789.1
    UniProtKB/TrEMBL
    A2RSL0, B7ZN60
    Related
    ENSMUSP00000064527.6, ENSMUST00000070390.12
    Conserved Domains (2) summary
    smart00020
    Location:207 → 438
    Tryp_SPc; Trypsin-like serine protease
    pfam15494
    Location:106 → 203
    SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    49013994..49028891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155414.1 → XP_036011307.1  transmembrane protease serine 5 isoform X3

    UniProtKB/TrEMBL
    E9PWX9
    Conserved Domains (2) summary
    smart00020
    Location:73 → 304
    Tryp_SPc; Trypsin-like serine protease
    pfam15494
    Location:3 → 69
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. XM_006510709.3 → XP_006510772.1  transmembrane protease serine 5 isoform X1

    UniProtKB/TrEMBL
    Q8CDR0
    Related
    ENSMUSP00000131650.2, ENSMUST00000167095.8
    Conserved Domains (2) summary
    smart00020
    Location:184 → 415
    Tryp_SPc; Trypsin-like serine protease
    pfam15494
    Location:83 → 180
    SRCR_2; Scavenger receptor cysteine-rich domain

RNA

  1. XR_004935609.1 RNA Sequence

  2. XR_004935610.1 RNA Sequence

  3. XR_001779076.2 RNA Sequence

    Related
    ENSMUST00000166272.8

  4. XR_001779075.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER04.3 GenPept UniProtKB/Swiss-Prot:Q9ER04

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