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PF3D7_0412400 erythrocyte membrane protein 1, PfEMP1 [ Plasmodium falciparum 3D7 ]

Gene ID: 812583, updated on 14-Nov-2024

Summary

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Gene symbol
PF3D7_0412400
Gene description
erythrocyte membrane protein 1, PfEMP1
Locus tag
PF3D7_0412400
See related
PlasmoDB:PF3D7_0412400; VEuPathDB:PF3D7_0412400
Gene type
protein coding
RNA name
erythrocyte membrane protein 1, PfEMP1
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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See PF3D7_0412400 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
2
Sequence:
Chromosome: 4; NC_004318.2 (545987..553810, complement)

Chromosome 4 - NC_004318.2Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene phosphopantothenoylcysteine synthetase, putative Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004318.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antigenic variation in Plasmodium falciparum. Scherf A, et al. Annu Rev Microbiol, 2008. PMID 18785843
  2. Variant antigens of Plasmodium falciparum encoded by the var multigenic family are multifunctional macromolecules. Nogueira PA, et al. Res Microbiol, 2001 Mar. PMID 11316367
  3. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Rowe JA, et al. Nature, 1997 Jul 17. PMID 9230440
  4. Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion. Craig A, et al. Mol Biochem Parasitol, 2001 Jul. PMID 11420100
  5. A recombinant peptide based on PfEMP-1 blocks and reverses adhesion of malaria-infected red blood cells to CD36 under flow. Cooke BM, et al. Mol Microbiol, 1998 Oct. PMID 9786187

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables cell adhesion molecule binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adhesion of symbiont to microvasculature TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within antigenic variation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cell-cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within symbiont-mediated perturbation of host erythrocyte aggregation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in host cell plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in infected host cell surface knob TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
erythrocyte membrane protein 1, PfEMP1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004318.2 Reference assembly

    Range
    545987..553810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351399.1 → XP_001351435.1  erythrocyte membrane protein 1, PfEMP1 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351435.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I0BZJ7, Q9U0G6
    Conserved Domains (5) summary
    PTZ00176
    Location:1 → 469
    PTZ00176; erythrocyte membrane protein 1 (PfEMP1); Provisional
    pfam03011
    Location:1479 → 1628
    PFEMP; PFEMP DBL domain
    pfam15445
    Location:1746 → 2209
    ATS; acidic terminal segments, variant surface antigen of PfEMP1
    pfam05424
    Location:121 → 328
    Duffy_binding; Duffy binding domain
    pfam18562
    Location:1404 → 1456
    CIDR1_gamma; Cysteine-Rich Interdomain Region 1 gamma
Nucleotide Protein
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