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PF3D7_1345100 thioredoxin 2 [ Plasmodium falciparum 3D7 ]

Gene ID: 813783, updated on 12-Sep-2024

Summary

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Gene symbol
PF3D7_1345100
Gene description
thioredoxin 2
Locus tag
PF3D7_1345100
See related
PlasmoDB:PF3D7_1345100; VEuPathDB:PF3D7_1345100
Gene type
protein coding
RNA name
thioredoxin 2
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Genomic context

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See PF3D7_1345100 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
4
Sequence:
Chromosome: 13; NC_004331.3 (1809736..1810521, complement)

Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene rhomboid protease ROM6, putative Neighboring gene conserved Plasmodium protein, unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004331.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery. Sharma A, et al. Sci Rep, 2011. PMID 22355694, Free PMC Article
  2. Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum. Boucher IW, et al. Mol Microbiol, 2006 Aug. PMID 16879648, Free PMC Article
  3. A newly discovered protein export machine in malaria parasites. de Koning-Ward TF, et al. Nature, 2009 Jun 18. PMID 19536257, Free PMC Article
  4. Compartmentation of redox metabolism in malaria parasites. Kehr S, et al. PLoS Pathog, 2010 Dec 23. PMID 21203490, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The P. falciparum mitochondrial peroxiredoxin is dependent on peroxidase with a preference for H2O2, and it has an important function in detoxification of reactive oxygen in the parasite's mitochondrion.
    Title: Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum.
  2. PfTrx-2 adopts a canonical thioredoxin fold but with significant structural differences in its N-terminus.
    Title: Structural insights into thioredoxin-2: a component of malaria parasite protein secretion machinery.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Component Evidence Code Pubs
part_of PTEX complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in symbiont-containing vacuole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thioredoxin 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004331.3 Reference assembly

    Range
    1809736..1810521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001350130.1 → XP_001350166.1  thioredoxin 2 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001350166.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8IDP4
    UniProtKB/TrEMBL
    W4IA74, W7F2S1, W7FZ55, W7JP69
    Conserved Domains (1) summary
    cd02947
    Location:69 → 154
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
Nucleotide Protein
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