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OR2AE1 olfactory receptor family 2 subfamily AE member 1 [ Homo sapiens (human) ]

Gene ID: 81392, updated on 10-Dec-2024

Summary

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Official Symbol
OR2AE1provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily AE member 1provided by HGNC
Primary source
HGNC:HGNC:15087
See related
Ensembl:ENSG00000244623 AllianceGenome:HGNC:15087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2AE2
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
all
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Genomic context

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See OR2AE1 in Genome Data Viewer
Location:
7q22.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99876062..99877033, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101115564..101116535, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99473685..99474656, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 3 subfamily A member 43 Neighboring gene MPRA-validated peak6657 silencer Neighboring gene cytochrome P450 family 3 subfamily A member 52, pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:99484893-99485660 Neighboring gene tripartite motif containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26329 Neighboring gene uncharacterized LOC101927610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26330 Neighboring gene gap junction protein gamma 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence diversity and haplotype structure at the human CYP3A cluster. Thompson EE, et al. Pharmacogenomics J, 2006 Mar-Apr. PMID 16314882
  2. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 2AE1
Names
olfactory receptor 2AE2
olfactory receptor, family 2, subfamily AE, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005276.1 → NP_001005276.1  olfactory receptor 2AE1

    See identical proteins and their annotated locations for NP_001005276.1

    Status: VALIDATED

    Source sequence(s)
    AB065478
    Consensus CDS
    CCDS34696.1
    UniProtKB/Swiss-Prot
    B2RPD2, Q8NHA4
    UniProtKB/TrEMBL
    A0A126GVB7
    Related
    ENSP00000313936.2, ENST00000316368.3
    Conserved Domains (1) summary
    cd15421
    Location:25 → 300
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    99876062..99877033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101115564..101116535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NHA4.1 GenPept UniProtKB/Swiss-Prot:Q8NHA4

Gene LinkOut

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