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GPR63 G protein-coupled receptor 63 [ Homo sapiens (human) ]

Gene ID: 81491, updated on 4-Jan-2025

Summary

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Official Symbol
GPR63provided by HGNC
Official Full Name
G protein-coupled receptor 63provided by HGNC
Primary source
HGNC:HGNC:13302
See related
Ensembl:ENSG00000112218 MIM:606915; AllianceGenome:HGNC:13302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSP24B; PSP24(beta)
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in testis (RPKM 1.6), brain (RPKM 1.0) and 21 other tissues See more
Orthologs
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Genomic context

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See GPR63 in Genome Data Viewer
Location:
6q16.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (96794125..96837477, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (97965926..98009403, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (97242001..97285353, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:97210120-97210694 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 6 Neighboring gene MPRA-validated peak5968 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24846 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 Neighboring gene RNA, 7SL, cytoplasmic 509, pseudogene Neighboring gene kelch like family member 32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Endothelial cell-derived S1P promotes migration and stemness by binding with GPR63 in colorectal cancer. Zeng S, et al. Pathol Res Pract, 2022 Dec. PMID 36371997
  2. Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. Niedernberg A, et al. Cell Signal, 2003 Apr. PMID 12618218
  3. Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems. Kawasawa Y, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027575
  4. Identification of four novel human G protein-coupled receptors expressed in the brain. Lee DK, et al. Brain Res Mol Brain Res, 2001 Jan 31. PMID 11165367
  5. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Kawasawa Y, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027574

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial cell-derived S1P promotes migration and stemness by binding with GPR63 in colorectal cancer.
    Title: Endothelial cell-derived S1P promotes migration and stemness by binding with GPR63 in colorectal cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
probable G-protein coupled receptor 63
Names
PSP24-2
PSP24-beta
brain expressed G-protein-coupled receptor PSP24 beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143957.3 → NP_001137429.1  probable G-protein coupled receptor 63

    See identical proteins and their annotated locations for NP_001137429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AI208851, AK289839, AK313535, AL033379, DA242987, DB119067
    Consensus CDS
    CCDS5036.1
    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9
    Conserved Domains (1) summary
    cd15404
    Location:82 → 382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_030784.4 → NP_110411.1  probable G-protein coupled receptor 63

    See identical proteins and their annotated locations for NP_110411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AI208851, AK289839, AK313535, AL033379, DA242987
    Consensus CDS
    CCDS5036.1
    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9
    Related
    ENSP00000229955.2, ENST00000229955.4
    Conserved Domains (1) summary
    cd15404
    Location:82 → 382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    96794125..96837477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536155.2 → XP_011534457.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_011534457.1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9
    Conserved Domains (1) summary
    cd15404
    Location:82 → 382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_011536159.2 → XP_011534461.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_011534461.1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9
    Conserved Domains (1) summary
    cd15404
    Location:82 → 382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_011536157.3 → XP_011534459.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_011534459.1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9
    Conserved Domains (1) summary
    cd15404
    Location:82 → 382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_017011334.2 → XP_016866823.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9
    Conserved Domains (1) summary
    cd15404
    Location:82 → 382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_011536154.3 → XP_011534456.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_011534456.1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9
    Conserved Domains (1) summary
    cd15404
    Location:82 → 382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. XM_011536153.2 → XP_011534455.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_011534455.1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9
    Conserved Domains (1) summary
    cd15404
    Location:82 → 382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  7. XM_006715570.5 → XP_006715633.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_006715633.1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9
    Conserved Domains (1) summary
    cd15404
    Location:82 → 382
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    97965926..98009403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356483.1 → XP_054212458.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9

  2. XM_054356484.1 → XP_054212459.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9

  3. XM_054356482.1 → XP_054212457.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9

  4. XM_054356485.1 → XP_054212460.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9

  5. XM_054356486.1 → XP_054212461.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9

  6. XM_054356487.1 → XP_054212462.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/Swiss-Prot
    Q9BZJ6, Q9UJH3
    UniProtKB/TrEMBL
    A8K1C4, Q6NWR8, Q6NWR9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BZJ6.2 GenPept UniProtKB/Swiss-Prot:Q9BZJ6

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