HEN2 RNA helicase, ATP-dependent, SK12/DOB1 protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HEN2
Official Full Name: RNA helicase, ATP-dependent, SK12/DOB1 protein
Primary source: TAIR:AT2G06990
Locus tag: AT2G06990
See related: Araport:AT2G06990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: hua enhancer 2; T4E14.10; T4E14_10
Summary: encodes a putative DExH-box RNA helicase that acts redundantly with HEN1, HUA1, and HUA2 in the specification of floral organ identity in the third whorl.
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Genomic context

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See HEN2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 16

Sequence:: Chromosome: 2; NC_003071.7 (2894904..2902020)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis SMN2/HEN2, Encoding DEAD-Box RNA Helicase, Governs Proper Expression of the Resistance Gene SMN1/RPS6 and Is Involved in Dwarf, Autoimmune Phenotypes of mekk1 and mpk4 Mutants.
Title: Arabidopsis SMN2/HEN2, Encoding DEAD-Box RNA Helicase, Governs Proper Expression of the Resistance Gene SMN1/RPS6 and Is Involved in Dwarf, Autoimmune Phenotypes of mekk1 and mpk4 Mutants.
SERRATE interacts with the nuclear exosome targeting (NEXT) complex to degrade primary miRNA precursors in Arabidopsis.
Title: SERRATE interacts with the nuclear exosome targeting (NEXT) complex to degrade primary miRNA precursors in Arabidopsis.
We show that the Arabidopsis core exosome can associate with two related RNA helicases, AtMTR4 and HEN2
Title: The RNA helicases AtMTR4 and HEN2 target specific subsets of nuclear transcripts for degradation by the nuclear exosome in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_126675.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within RNA metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in mRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within specification of floral organ identity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: RNA helicase, ATP-dependent, SK12/DOB1 protein

NP_565338.1

hua enhancer 2 (HEN2); CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DSH, C-terminal (InterPro:IPR012961), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), RNA helicase, ATP-dependent, SK12/DOB1 (InterPro:IPR016438), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: RNA helicase, ATP-dependent, SK12/DOB1 protein (TAIR:AT1G59760.1); Has 9841 Blast hits to 8173 proteins in 1240 species: Archae - 753; Bacteria - 3176; Metazoa - 1197; Fungi - 1159; Plants - 489; Viruses - 32; Other Eukaryotes - 3035 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

2894904..2902020

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126675.3 → NP_565338.1 RNA helicase, ATP-dependent, SK12/DOB1 protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565338.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q941F4, Q9ZVW2

UniProtKB/TrEMBL

A0A178VT15, A0A5S9WXJ8, A0A7G2E7R3

Conserved Domains (1) summary

COG4581
Location:34 → 995

Dob10; Superfamily II RNA helicase [Replication, recombination and repair]