MCM5 Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MCM5
Official Full Name: Minichromosome maintenance (MCM2/3/5) family protein
Primary source: TAIR:AT2G07690
Locus tag: AT2G07690
See related: Araport:AT2G07690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MINICHROMOSOME MAINTENANCE 5
Summary: Member of the minichromosome maintenance complex, involved in DNA replication initiation. Abundant in proliferating and endocycling tissues. Localized in the nucleus during G1, S and G2 phases of the cell cycle, and are released into the cytoplasmic compartment during mitosis. Binds chromatin.
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Genomic context

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See MCM5 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 18

Sequence:: Chromosome: 2; NC_003071.7 (3522984..3527500, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endogenous MCM5 and MCM7 proteins are localized in the nucleus during G1, S, and G2 phases of the cell cycle and are released into the cytoplasmic compartment during mitosis.[MCM5]
Title: Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001202592.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA replication origin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA unwinding involved in DNA replication	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of MCM complex	IEA Inferred from Electronic Annotation more info
part_of THO complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Minichromosome maintenance (MCM2/3/5) family protein

NP_001189521.1

MINICHROMOSOME MAINTENANCE 5 (MCM5); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: cell proliferation, DNA-dependent DNA replication initiation, DNA unwinding involved in replication; LOCATED IN: nuclear chromatin, nucleus, cytoplasm; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 5 (InterPro:IPR008048); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1).

NP_178812.1

MINICHROMOSOME MAINTENANCE 5 (MCM5); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: cell proliferation, DNA-dependent DNA replication initiation, DNA unwinding involved in replication; LOCATED IN: nuclear chromatin, nucleus, cytoplasm; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 5 (InterPro:IPR008048); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1); Has 3980 Blast hits to 3841 proteins in 547 species: Archae - 376; Bacteria - 145; Metazoa - 1209; Fungi - 933; Plants - 431; Viruses - 3; Other Eukaryotes - 883 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

3522984..3527500 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126771.6 → NP_178812.1 Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_178812.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O80786

UniProtKB/TrEMBL

A0A178U732, A0A5S9XQ83

Conserved Domains (2) summary

smart00350
Location:131 → 644

MCM; minichromosome maintenance proteins

pfam14551
Location:34 → 126

MCM_N; MCM N-terminal domain
NM_001202592.1 → NP_001189521.1 Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189521.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XQ83, F4INF9

Conserved Domains (3) summary

smart00350
Location:131 → 642

MCM; minichromosome maintenance proteins

pfam14551
Location:34 → 148

MCM_N; MCM N-terminal domain

cl21455
Location:368 → 507

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases