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SERK4 somatic embryogenesis receptor-like kinase 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 815862, updated on 18-Sep-2024

Summary

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Official Symbol
SERK4
Official Full Name
somatic embryogenesis receptor-like kinase 4
Primary source
TAIR:AT2G13790
Locus tag
AT2G13790
See related
Araport:AT2G13790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AT2G13780; ATSERK4; BAK1-LIKE 1; BAK7; BKK1; BRI1- ASSOCIATED KINASE 7; BRI1- ASSOCIATED KINASE 7; F13J11.14; F13J11_14; somatic embryogenesis receptor-like kinase 4; SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 4
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Genomic context

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See SERK4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Sequence:
Chromosome: 2; NC_003071.7 (5741592..5746833)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene no-apical-meristem-associated carboxy-terminal domain protein Neighboring gene ncRNA Neighboring gene nuclease Neighboring gene somatic embryogenesis receptor-like kinase 5 Neighboring gene AGD2-like defense response protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BAK7 displays unequal genetic redundancy with BAK1 in brassinosteroid signaling and early senescence in Arabidopsis. Jeong YJ, et al. Mol Cells, 2010 Mar. PMID 20108170
  2. Characterization of Somatic Embryogenesis Receptor-Like Kinase 4 as a Negative Regulator of Leaf Senescence in Arabidopsis. Li X, et al. Cells, 2019 Jan 14. PMID 30646631, Free PMC Article
  3. The Arabidopsis leucine-rich repeat receptor-like kinases BAK1/SERK3 and BKK1/SERK4 are required for innate immunity to hemibiotrophic and biotrophic pathogens. Roux M, et al. Plant Cell, 2011 Jun. PMID 21693696, Free PMC Article
  4. Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death. Wu Y, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33055218, Free PMC Article
  5. BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways. He K, et al. Curr Biol, 2007 Jul 3. PMID 17600708

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death.
    Title: Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death.
  2. In this study, the SERK4 gene was found to be highly expressed in senescent leaves and to control leaf senescence in Arabidopsis.
    Title: Characterization of Somatic Embryogenesis Receptor-Like Kinase 4 as a Negative Regulator of Leaf Senescence in Arabidopsis.
  3. N-glycosylation and specific ERQC components are essential to activate bak1/serk4 cell death, and CRK4 is likely to be among client proteins of protein glycosylation involved in BAK1/SERK4-regulated cell death.
    Title: Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation.
  4. Oligogalacturonides are sensed through multiple and partially redundant perception/transduction complexes, some targeted by AvrPto, but not necessarily comprising BAK1 and BKK1.
    Title: Immune responses induced by oligogalacturonides are differentially affected by AvrPto and loss of BAK1/BKK1 and PEPR1/PEPR2.
  5. SERK3 and SERK4 have diverged from the original SERK protein in both their extracellular and cytoplasmic domains.
    Title: On the Origin of SERKs: Bioinformatics Analysis of the Somatic Embryogenesis Receptor Kinases.
  6. serk1 bak1 bkk1 triple mutant exhibited drastically reduced expression of a number of genes critical to polar auxin transport, cell cycle, endodermis development and root meristem differentiatio
    Title: Somatic embryogenesis receptor kinases control root development mainly via brassinosteroid-independent actions in Arabidopsis thaliana.
  7. Data reveal that PAMP-triggered immunity (PTI) relies on ligand-induced recruitment of SERK3/4 and provides insight into the early PTI signaling events underlying this important layer of plant innate immunity.
    Title: The Arabidopsis leucine-rich repeat receptor-like kinases BAK1/SERK3 and BKK1/SERK4 are required for innate immunity to hemibiotrophic and biotrophic pathogens.
  8. BAK7 (SERK4) is a component of the brassinosteroid signaling pathway, with varying degrees of genetic redundancy with BAK1. It affects plant growth via BL-independent pathways in vivo.
    Title: BAK7 displays unequal genetic redundancy with BAK1 in brassinosteroid signaling and early senescence in Arabidopsis.
  9. study demonstrates that BAK1 and BKK1 (AtSERK4) have dual physiological roles: positively regulating a brassinosteroid (BR)-dependent plant growth pathway, and negatively regulating a BR-independent cell-death pathway
    Title: BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_126955.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor serine/threonine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane receptor protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brassinosteroid mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
acts_upstream_of_or_within leaf senescence IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within plant-type hypersensitive response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in seedling development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
somatic embryogenesis receptor-like kinase 4
NP_178999.2
  • somatic embryogenesis receptor-like kinase 4 (SERK4); FUNCTIONS IN: protein kinase activity, transmembrane receptor protein serine/threonine kinase activity; INVOLVED IN: in 6 processes; LOCATED IN: endomembrane system; EXPRESSED IN: rosette leaf, cauline leaf, fruit, root, flower; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: somatic embryogenesis receptor-like kinase 5 (TAIR:AT2G13800.1); Has 172318 Blast hits to 120437 proteins in 4454 species: Archae - 129; Bacteria - 14524; Metazoa - 44355; Fungi - 9158; Plants - 84468; Viruses - 411; Other Eukaryotes - 19273 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    5741592..5746833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126955.5 → NP_178999.2  somatic embryogenesis receptor-like kinase 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178999.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WW00, Q93ZV3, Q9SKG5
    UniProtKB/TrEMBL
    A0A5S9WXY1
    Conserved Domains (4) summary
    smart00221
    Location:295 → 568
    STYKc; Protein kinase; unclassified specificity
    sd00033
    Location:101 → 124
    LRR_RI; leucine-rich repeat [structural motif]
    pfam08263
    Location:30 → 72
    LRRNT_2; Leucine rich repeat N-terminal domain
    cl21453
    Location:300 → 571
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SKG5.2

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