U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Egfl8 EGF-like domain 8 [ Mus musculus (house mouse) ]

Gene ID: 81701, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Egfl8provided by MGI
Official Full Name
EGF-like domain 8provided by MGI
Primary source
MGI:MGI:1932094
See related
Ensembl:ENSMUSG00000015467 AllianceGenome:MGI:1932094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ng3
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in vasculogenesis. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including diaphragm; genitourinary system; gut; hemolymphoid system gland; and trigeminal nerve. Orthologous to human EGFL8 (EGF like domain multiple 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in duodenum adult (RPKM 162.7), small intestine adult (RPKM 77.7) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Egfl8 in Genome Data Viewer
Location:
17 B1; 17 18.19 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34832174..34835536, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34613349..34616562, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene STARR-positive B cell enhancer ABC_E45 Neighboring gene ring finger protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E11640 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene RIKEN cDNA 2610029K11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34767227-34767451 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34768061-34768244 Neighboring gene proline-rich transmembrane protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Descriptive and functional characterization of epidermal growth factor‑like domain 8 in mouse cortical thymic epithelial cells by integrated analysis of gene expression signatures and networks. Lim YS, et al. Int J Mol Med, 2021 Mar. PMID 33448309, Free PMC Article
  2. Molecular characterization and expression analysis of mouse epidermal growth factor-like domain 8. Song IJ, et al. Int J Mol Med, 2015 Aug. PMID 26096343
  3. Epidermal growth factor-like domain 8 inhibits the survival and proliferation of mouse thymocytes. Subhan F, et al. Int J Mol Med, 2013 Oct. PMID 23877103
  4. Regulatory role of mouse epidermal growth factor-like protein 8 in thymic epithelial cells. Choi HJ, et al. Biochem Biophys Res Commun, 2012 Aug 24. PMID 22828506
  5. Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Fitch MJ, et al. Dev Dyn, 2004 Jun. PMID 15162510, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Descriptive and functional characterization of epidermal growth factorlike domain 8 in mouse cortical thymic epithelial cells by integrated analysis of gene expression signatures and networks.
    Title: Descriptive and functional characterization of epidermal growth factor‑like domain 8 in mouse cortical thymic epithelial cells by integrated analysis of gene expression signatures and networks.
  2. Mouse EGFL8 encodes a protein of 293 amino acids with two EGFL domains, an Emilin-like domain and a Ca(2+)-binding EGFL domain, which has a molecular mass of 32 kDa.
    Title: Molecular characterization and expression analysis of mouse epidermal growth factor-like domain 8.
  3. EGFL8 inhibited thymocyte proliferation and induced thymocyte apoptosis.
    Title: Epidermal growth factor-like domain 8 inhibits the survival and proliferation of mouse thymocytes.
  4. these data show that EGFL8 exerts inhibitory effects on thymic epithelial cells and thymocytes, suggesting that EGFL8 acts as a negative regulatory molecule in the development of T cells in the mouse thymus.
    Title: Regulatory role of mouse epidermal growth factor-like protein 8 in thymic epithelial cells.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
NOT involved_in in utero embryonic development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in vasculogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
epidermal growth factor-like protein 8
Names
EGF-like protein 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403845.1 → NP_001390774.1  epidermal growth factor-like protein 8 precursor

    Status: VALIDATED

    Source sequence(s)
    CT009767
    UniProtKB/Swiss-Prot
    O35447, Q3UFB4, Q6GUQ1
    UniProtKB/TrEMBL
    B9EJ41

  2. NM_152922.4 → NP_690886.3  epidermal growth factor-like protein 8 precursor

    See identical proteins and their annotated locations for NP_690886.3

    Status: VALIDATED

    Source sequence(s)
    CT009767
    Consensus CDS
    CCDS28651.1
    UniProtKB/Swiss-Prot
    O35447, Q3UFB4, Q6GUQ1
    UniProtKB/TrEMBL
    B7ZP51, B9EJ41
    Related
    ENSMUSP00000015611.8, ENSMUST00000015611.14
    Conserved Domains (2) summary
    smart00179
    Location:144 → 183
    EGF_CA; Calcium-binding EGF-like domain
    pfam07546
    Location:37 → 101
    EMI; EMI domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34832174..34835536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525180.5 → XP_006525243.1  epidermal growth factor-like protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006525243.1

    UniProtKB/TrEMBL
    E9QAK9
    Related
    ENSMUSP00000128433.3, ENSMUST00000168353.4
    Conserved Domains (2) summary
    smart00179
    Location:144 → 183
    EGF_CA; Calcium-binding EGF-like domain
    pfam07546
    Location:37 → 101
    EMI; EMI domain

  2. XM_036160852.1 → XP_036016745.1  epidermal growth factor-like protein 8 isoform X1

    UniProtKB/Swiss-Prot
    O35447, Q3UFB4, Q6GUQ1
    UniProtKB/TrEMBL
    B7ZP51, B9EJ41
    Conserved Domains (2) summary
    smart00179
    Location:144 → 183
    EGF_CA; Calcium-binding EGF-like domain
    pfam07546
    Location:37 → 101
    EMI; EMI domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GUQ1.2 GenPept UniProtKB/Swiss-Prot:Q6GUQ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools