PLA2A phospholipase A 2A [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PLA2A
Official Full Name: phospholipase A 2A
Primary source: TAIR:AT2G26560
Locus tag: AT2G26560
See related: Araport:AT2G26560
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: PATATIN-LIKE PROTEIN 2; phospholipase A 2A; PHOSPHOLIPASE A 2A; PLA IIA; PLAII alpha; PLP2; T9J22.23; T9J22_23
Summary: Encodes a lipid acyl hydrolase with wide substrate specificity that accumulates upon infection by fungal and bacterial pathogens. Protein is localized in the cytoplasm in healthy leaves, and in membranes in infected cells. Plays a role in cell death and differentially affects the accumulation of oxylipins. Contributes to resistance to virus.
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Genomic context

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See PLA2A in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 6

Sequence:: Chromosome: 2; NC_003071.7 (11293702..11295918, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLP2 contributes to resistance to Cucumber mosaic virus, plays an essential role in cell death, and differentially affects biosynthesis of oxylipins and resistance to pathogens.
Title: The Arabidopsis patatin-like protein 2 (PLP2) plays an essential role in cell death execution and differentially affects biosynthesis of oxylipins and resistance to pathogens.
PLP2 is a pathogen-inducible patatin-like lipid acyl hydrolase that can be exploited by pathogens to facilitate host colonization.[PLP2]
Title: A pathogen-inducible patatin-like lipid acyl hydrolase facilitates fungal and bacterial host colonization in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_128213.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within oxylipin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	HDA more info	PubMed

General protein information

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Preferred Names: phospholipase A 2A

NP_180224.1

phospholipase A 2A (PLA2A); FUNCTIONS IN: lipase activity, nutrient reservoir activity; INVOLVED IN: in 6 processes; LOCATED IN: membrane, cytoplasm; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Acyl transferase/acyl hydrolase/lysophospholipase (InterPro:IPR016035), Patatin (InterPro:IPR002641); BEST Arabidopsis thaliana protein match is: Acyl transferase/acyl hydrolase/lysophospholipase superfamily protein (TAIR:AT4G37070.2); Has 2114 Blast hits to 2104 proteins in 375 species: Archae - 0; Bacteria - 479; Metazoa - 231; Fungi - 198; Plants - 897; Viruses - 0; Other Eukaryotes - 309 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

11293702..11295918 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128213.4 → NP_180224.1 phospholipase A 2A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180224.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O48723, Q8LDK8

UniProtKB/TrEMBL

A0A178VSV3, A0A5S9X1E3

Conserved Domains (1) summary

cd07214
Location:16 → 366

Pat17_isozyme_like; Patatin-like phospholipase of plants