U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OTLD1 OTU-like cysteine protease family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817278, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
OTLD1
Official Full Name
OTU-like cysteine protease family protein
Primary source
TAIR:AT2G27350
Locus tag
AT2G27350
See related
Araport:AT2G27350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F12K2.7; F12K2_7; otubain-like deubiquitinase 1
Summary
Encodes an otubain-like histone deubiquitinase involved in chromatin modification and regulation of plant gene expression.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See OTLD1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Sequence:
Chromosome: 2; NC_003071.7 (11699548..11704303, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene NEP-interacting protein, putative (DUF239) Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene N-acetylglucosaminylphosphatidylinositol de-N-acetylase family protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene Uncharacterized protein family (UPF0497)

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Activation of gene expression by histone deubiquitinase OTLD1. Keren I, et al. Epigenetics, 2017 Jul 3. PMID 28703681, Free PMC Article
  2. The histone deubiquitinase OTLD1 targets euchromatin to regulate plant growth. Keren I, et al. Sci Signal, 2016 Dec 20. PMID 27999174, Free PMC Article
  3. Arabidopsis LSH10 transcription factor and OTLD1 histone deubiquitinase interact and transcriptionally regulate the same target genes. Vo Phan MS, et al. Commun Biol, 2023 Jan 17. PMID 36650214, Free PMC Article
  4. Involvement of KDM1C histone demethylase-OTLD1 otubain-like histone deubiquitinase complexes in plant gene repression. Krichevsky A, et al. Proc Natl Acad Sci U S A, 2011 Jul 5. PMID 21690391, Free PMC Article
  5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis LSH10 transcription factor and OTLD1 histone deubiquitinase interact and transcriptionally regulate the same target genes.
    Title: Arabidopsis LSH10 transcription factor and OTLD1 histone deubiquitinase interact and transcriptionally regulate the same target genes.
  2. OTLD1 can play a dual role in transcriptional repression and activation of its target genes via target chromatin remodeling.
    Title: Activation of gene expression by histone deubiquitinase OTLD1.
  3. these data indicate that OTLD1 promotes the concerted epigenetic regulation of a set of genes that collectively limit plant growth.
    Title: The histone deubiquitinase OTLD1 targets euchromatin to regulate plant growth.
  4. Otubain-like deubiquitinase, OTLD1, directly interacts with Arabidopsis KDM1C in vivo; both of them are involved in transcriptional gene repression via histone deubiquitination and demethylation. [OTLD1]
    Title: Involvement of KDM1C histone demethylase-OTLD1 otubain-like histone deubiquitinase complexes in plant gene repression.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Miscellaneous features

  • Loc: c11702537-11702406 AT2G27350.uORF1
NM_001202687.2
NM_128294.2
NM_179768.4
NM_201815.2
NM_201816.5
NM_201817.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
OTU-like cysteine protease family protein
NP_001189616.1
  • OTU-like cysteine protease family protein; FUNCTIONS IN: cysteine-type peptidase activity; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ovarian tumour, otubain (InterPro:IPR003323); BEST Arabidopsis thaliana protein match is: SEC-C motif-containing protein / OTU-like cysteine protease family protein (TAIR:AT5G67170.2).
NP_565648.1
  • OTU-like cysteine protease family protein; FUNCTIONS IN: cysteine-type peptidase activity; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ovarian tumour, otubain (InterPro:IPR003323); BEST Arabidopsis thaliana protein match is: SEC-C motif-containing protein / OTU-like cysteine protease family protein (TAIR:AT5G67170.2); Has 2113 Blast hits to 1438 proteins in 217 species: Archae - 0; Bacteria - 20; Metazoa - 656; Fungi - 244; Plants - 357; Viruses - 15; Other Eukaryotes - 821 (source: NCBI BLink).
NP_850099.1
  • OTU-like cysteine protease family protein; FUNCTIONS IN: cysteine-type peptidase activity; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ovarian tumour, otubain (InterPro:IPR003323); BEST Arabidopsis thaliana protein match is: SEC-C motif-containing protein / OTU-like cysteine protease family protein (TAIR:AT5G67170.2); Has 2113 Blast hits to 1438 proteins in 217 species: Archae - 0; Bacteria - 20; Metazoa - 656; Fungi - 244; Plants - 357; Viruses - 15; Other Eukaryotes - 821 (source: NCBI BLink).
NP_973544.1
  • OTU-like cysteine protease family protein; FUNCTIONS IN: cysteine-type peptidase activity; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ovarian tumour, otubain (InterPro:IPR003323); BEST Arabidopsis thaliana protein match is: SEC-C motif-containing protein / OTU-like cysteine protease family protein (TAIR:AT5G67170.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_973545.2
  • OTU-like cysteine protease family protein; FUNCTIONS IN: cysteine-type peptidase activity; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ovarian tumour, otubain (InterPro:IPR003323); BEST Arabidopsis thaliana protein match is: SEC-C motif-containing protein / OTU-like cysteine protease family protein (TAIR:AT5G67170.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_973546.2
  • OTU-like cysteine protease family protein; FUNCTIONS IN: cysteine-type peptidase activity; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ovarian tumour, otubain (InterPro:IPR003323); BEST Arabidopsis thaliana protein match is: SEC-C motif-containing protein / OTU-like cysteine protease family protein (TAIR:AT5G67170.2); Has 1771 Blast hits to 1440 proteins in 217 species: Archae - 0; Bacteria - 18; Metazoa - 660; Fungi - 248; Plants - 357; Viruses - 15; Other Eukaryotes - 473 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    11699548..11704303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179768.4 → NP_850099.1  OTU-like cysteine protease family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850099.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IFS7, Q93Z76, Q9XIP2
    UniProtKB/TrEMBL
    A0A178VTT9, A0A654EWN6
    Conserved Domains (1) summary
    cl19932
    Location:224 → 333
    OTU; OTU-like cysteine protease

  2. NM_201816.5 → NP_973545.2  OTU-like cysteine protease family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973545.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VVD1
    Conserved Domains (1) summary
    cl19932
    Location:224 → 333
    OTU; OTU-like cysteine protease

  3. NM_201817.2 → NP_973546.2  OTU-like cysteine protease family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973546.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VVD1
    Conserved Domains (1) summary
    cl19932
    Location:224 → 333
    OTU; OTU-like cysteine protease

  4. NM_201815.2 → NP_973544.1  OTU-like cysteine protease family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VVD1
    Conserved Domains (1) summary
    cl19932
    Location:224 → 333
    OTU; OTU-like cysteine protease

  5. NM_128294.2 → NP_565648.1  OTU-like cysteine protease family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565648.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IFS7, Q93Z76, Q9XIP2
    UniProtKB/TrEMBL
    A0A178VTT9, A0A654EWN6
    Conserved Domains (1) summary
    cl19932
    Location:224 → 333
    OTU; OTU-like cysteine protease

  6. NM_001202687.2 → NP_001189616.1  OTU-like cysteine protease family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189616.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VVD1
    Conserved Domains (1) summary
    cl19932
    Location:224 → 333
    OTU; OTU-like cysteine protease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XIP2.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools