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Fez1 fasciculation and elongation protein zeta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81730, updated on 4-Jan-2025

Summary

Official Symbol
Fez1provided by RGD
Official Full Name
fasciculation and elongation protein zeta 1provided by RGD
Primary source
RGD:619708
See related
EnsemblRapid:ENSRNOG00000006075 AllianceGenome:RGD:619708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein kinase C binding activity. Involved in several processes, including hippocampus development; positive regulation of anterograde axonal transport of mitochondrion; and positive regulation of neuron projection development. Located in dendrite; growth cone; and neuronal cell body. Biomarker of Parkinson's disease. Orthologous to human FEZ1 (fasciculation and elongation protein zeta 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 1106.9) and Uterus (RPKM 45.3) See more
Orthologs
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Genomic context

See Fez1 in Genome Data Viewer
Location:
8q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (44733288..44778519)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (36544462..36589684)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39305128..39350270)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit A Neighboring gene EI24, autophagy associated transmembrane protein Neighboring gene 60S ribosomal protein L14 pseudogene Neighboring gene PBX/knotted 1 homeobox 2 Neighboring gene uncharacterized LOC120094114

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC105385

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fasciculation and elongation protein zeta-1
Names
protein kinase C-binding protein Zeta1
zygin I
zygin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031066.1NP_112328.1  fasciculation and elongation protein zeta-1

    See identical proteins and their annotated locations for NP_112328.1

    Status: PROVISIONAL

    Source sequence(s)
    U63740
    UniProtKB/Swiss-Prot
    P97577, Q62922
    UniProtKB/TrEMBL
    A6KRM5
    Related
    ENSRNOP00000008285.4, ENSRNOT00000008285.5
    Conserved Domains (1) summary
    pfam07763
    Location:58298
    FEZ; FEZ-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    44733288..44778519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266208.1XP_063122278.1  fasciculation and elongation protein zeta-1 isoform X1

  2. XM_063266210.1XP_063122280.1  fasciculation and elongation protein zeta-1 isoform X3

  3. XM_063266209.1XP_063122279.1  fasciculation and elongation protein zeta-1 isoform X1

  4. XM_039082202.2XP_038938130.1  fasciculation and elongation protein zeta-1 isoform X2

    UniProtKB/Swiss-Prot
    P97577, Q62922
    UniProtKB/TrEMBL
    A6KRM5
    Related
    ENSRNOP00000101366.1, ENSRNOT00000129566.1
    Conserved Domains (1) summary
    pfam07763
    Location:58298
    FEZ; FEZ-like protein