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Pde7a phosphodiesterase 7A [ Rattus norvegicus (Norway rat) ]

Gene ID: 81744, updated on 27-Nov-2024

Summary

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Official Symbol
Pde7aprovided by RGD
Official Full Name
phosphodiesterase 7Aprovided by RGD
Primary source
RGD:68391
See related
EnsemblRapid:ENSRNOG00000013048 AllianceGenome:RGD:68391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PDE7-1
Summary
Enables cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human PDE7A (phosphodiesterase 7A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 87.0), Spleen (RPKM 71.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pde7a in Genome Data Viewer
Location:
2q24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (103631655..103723057, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (101714767..101806853, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104042124..104134101, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 1 Neighboring gene mitochondrial fission regulator 1 Neighboring gene RAB5C, member RAS oncogene family, pseudogene 1 Neighboring gene uncharacterized LOC103691515

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo. Morales-Garcia JA, et al. Stem Cells, 2017 Feb. PMID 27538853
  2. Pharmacological profile of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on acute and chronic inflammation models. Yamamoto S, et al. Eur J Pharmacol, 2006 Nov 21. PMID 17010967
  3. Differential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organs. Miró X, et al. Synapse, 2001 Jun 1. PMID 11304758
  4. Differential distribution of rat PDE-7 mRNA in embryonic and adult rat brain. Hoffmann R, et al. Cell Biochem Biophys, 1998. PMID 9515162
  5. Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Bloom TJ, et al. Proc Natl Acad Sci U S A, 1996 Nov 26. PMID 8943082, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDE7 inhibition controls stem cell expansion in the subgranular zone of the dentate gyrus of the hippocampus (SGZ) and the subventricular zone (SVZ) in the adult rat brain.
    Title: Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo.
  2. results are consistent with PDE7A being involved in the regulation of cAMP signaling in many brain functions.
    Title: Differential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organs.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclic-nucleotide phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
high affinity 3',5'-cyclic-AMP phosphodiesterase 7A
Names
cAMP-specific phosphodiesterase 7A
high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
rolipram-insensitive phosphodiesterase type 7
NP_112342.1
XP_006232250.1
XP_008759102.1
XP_038959155.1
XP_038959156.1
XP_063138701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031080.1 → NP_112342.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    O08593
    UniProtKB/TrEMBL
    F1LM88
    Related
    ENSRNOP00000060777.1, ENSRNOT00000067725.4
    Conserved Domains (1) summary
    pfam00233
    Location:211 → 431
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    103631655..103723057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232188.5 → XP_006232250.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X1

    UniProtKB/Swiss-Prot
    O08593
    UniProtKB/TrEMBL
    A0A8I6A6L3
    Related
    ENSRNOP00000086827.1, ENSRNOT00000108651.2
    Conserved Domains (1) summary
    pfam00233
    Location:185 → 405
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. XM_008760880.4 → XP_008759102.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X2

    UniProtKB/Swiss-Prot
    O08593
    Related
    ENSRNOP00000111863.1, ENSRNOT00000143772.1
    Conserved Domains (1) summary
    pfam00233
    Location:155 → 375
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. XM_039103227.2 → XP_038959155.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X3

    Conserved Domains (1) summary
    pfam00233
    Location:65 → 285
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. XM_063282631.1 → XP_063138701.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X5

  5. XM_039103228.2 → XP_038959156.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X4

    Conserved Domains (1) summary
    cl21469
    Location:211 → 309
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

RNA

  1. XR_005500379.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08593.1 GenPept UniProtKB/Swiss-Prot:O08593

Gene LinkOut

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