PH1 pleckstrin homologue 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PH1
Official Full Name: pleckstrin homologue 1
Primary source: TAIR:AT2G29700
Locus tag: AT2G29700
See related: Araport:AT2G29700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATPH1; pleckstrin homologue 1; T27A16.20; T27A16_20
Summary: Encodes a protein containing one PH (pleckstrin homology) domain with a short N-terminal extension
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Genomic context

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See PH1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (12697226..12698291)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

show that loss of AtPH1 function leads to the mislocalization of the metal uptake transporter NRAMP1 to the vacuole, providing a rationale for the reversion of nramp3nramp4 phenotypes
Title: Phosphatidylinositol 3-phosphate-binding protein AtPH1 controls the localization of the metal transporter NRAMP1 in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_128524.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in peroxisome	HDA more info	PubMed

General protein information

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Preferred Names: pleckstrin homologue 1

NP_565687.1

pleckstrin homologue 1 (PH1); CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: Pleckstrin homology (PH) domain superfamily protein (TAIR:AT5G05710.1); Has 2358 Blast hits to 2352 proteins in 131 species: Archae - 0; Bacteria - 0; Metazoa - 1854; Fungi - 32; Plants - 108; Viruses - 3; Other Eukaryotes - 361 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

12697226..12698291

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128524.4 → NP_565687.1 pleckstrin homologue 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565687.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O82386, Q9ST43

UniProtKB/TrEMBL

A0A178W3K4, A0A5S9X2D6

Conserved Domains (1) summary

cd13276
Location:29 → 136

PH_AtPH1; Arabidopsis thaliana Pleckstrin homolog (PH) 1 (AtPH1) PH domain