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Rpl18 ribosomal protein L18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81766, updated on 27-Nov-2024

Summary

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Official Symbol
Rpl18provided by RGD
Official Full Name
ribosomal protein L18provided by RGD
Primary source
RGD:621182
See related
EnsemblRapid:ENSRNOG00000021035 AllianceGenome:RGD:621182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Involved in liver regeneration. Part of cytosolic large ribosomal subunit. Is active in synapse. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 18. Orthologous to human RPL18 (ribosomal protein L18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 1788.1), Thymus (RPKM 1549.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rpl18 in Genome Data Viewer
Location:
1q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105325269..105327911)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96188811..96191452)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101700910..101703551)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene D-box binding PAR bZIP transcription factor Neighboring gene sphingosine kinase 2 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4 Neighboring gene sulfotransferase family 2B member 1 Neighboring gene uncharacterized LOC134483107

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The primary structure of rat ribosomal protein L18. Devi KR, et al. DNA, 1988 Apr. PMID 3371159
  2. Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats. Sommer W, et al. Mol Psychiatry, 2001 Jan. PMID 11244494
  3. Coordinate regulation of ribosomal protein mRNA level in regenerating rat liver. Study with the corresponding mouse cloned cDNAs. Faliks D, et al. Nucleic Acids Res, 1982 Feb 11. PMID 6121318, Free PMC Article
  4. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. Peng J, et al. J Biol Chem, 2004 May 14. PMID 15020595
  5. Selective high-efficiency cross-linking of mammalian ribosomal proteins with cleavable thiol-directed heterobifunctional reagents: identification and binding directions of major protein complexes. Hultin T. Biochim Biophys Acta, 1986 Aug 15. PMID 3730400

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL18
Names
60S ribosomal protein L18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031102.2 → NP_112364.1  large ribosomal subunit protein eL18

    See identical proteins and their annotated locations for NP_112364.1

    Status: VALIDATED

    Source sequence(s)
    BC084727, CB577548
    UniProtKB/Swiss-Prot
    P12001
    UniProtKB/TrEMBL
    A6JB77, Q0QEW8
    Related
    ENSRNOP00000077861.2, ENSRNOT00000097220.2
    Conserved Domains (1) summary
    pfam17135
    Location:2 → 176
    Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105325269..105327911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229161.5 → XP_006229223.1  large ribosomal subunit protein eL18 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4M9, Q0QEW8
    Related
    ENSRNOP00000088224.1, ENSRNOT00000116041.2
    Conserved Domains (1) summary
    cl12022
    Location:16 → 192
    Ribosomal_L18e; Ribosomal protein L18e/L15
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12001.2 GenPept UniProtKB/Swiss-Prot:P12001

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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