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ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 [ Homo sapiens (human) ]

Gene ID: 81792, updated on 27-Nov-2024

Summary

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Official Symbol
ADAMTS12provided by HGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 12provided by HGNC
Primary source
HGNC:HGNC:14605
See related
Ensembl:ENSG00000151388 MIM:606184; AllianceGenome:HGNC:14605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO4389
Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 3.5), gall bladder (RPKM 2.0) and 19 other tissues See more
Orthologs
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Genomic context

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See ADAMTS12 in Genome Data Viewer
Location:
5p13.3-p13.2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (33523535..33891990, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (33638143..34013900, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (33523640..33892095, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374717 Neighboring gene TOMM40 pseudogene 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:33576148-33577347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15963 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:33604013-33605212 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:33612245-33613444 Neighboring gene ST3GAL5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22456 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:33788320-33789519 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:33850007-33850508 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:33891377-33891878 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:33891879-33892378 Neighboring gene RNA, U6 small nuclear 923, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:33931143-33931648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:33944338-33944838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:33944839-33945339 Neighboring gene solute carrier family 45 member 2 Neighboring gene relaxin family peptide receptor 3 Neighboring gene proteasome 26S subunit, ATPase, 6 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Regulation of chondrocyte differentiation by ADAMTS-12 metalloproteinase depends on its enzymatic activity. Bai XH, et al. Cell Mol Life Sci, 2009 Feb. PMID 19151918, Free PMC Article
  2. Expression of ADAMTS12 in colorectal cancer-associated stroma prevents cancer development and is a good prognostic indicator of colorectal cancer. Wang D, et al. Dig Dis Sci, 2011 Nov. PMID 21559743
  3. Genetic variations in the ADAMTS12 gene are associated with schizophrenia in Puerto Rican patients of Spanish descent. Bespalova IN, et al. Neuromolecular Med, 2012 Mar. PMID 22322903
  4. Association of ADAMTS12 polymorphisms with rheumatoid arthritis. Nah SS, et al. Mol Med Rep, 2012 Jul. PMID 22505177
  5. The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer. Moncada-Pazos A, et al. J Cell Sci, 2009 Aug 15. PMID 19638407

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts.
    Title: ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts.
  2. ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer.
    Title: ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer.
  3. ADAMTS12 is a stromal modulator in chronic liver disease.
    Title: ADAMTS12 is a stromal modulator in chronic liver disease.
  4. ADAMTS12 promotes oxaliplatin chemoresistance and angiogenesis in gastric cancer through VEGF upregulation.
    Title: ADAMTS12 promotes oxaliplatin chemoresistance and angiogenesis in gastric cancer through VEGF upregulation.
  5. MicroRNA-186 suppresses cell proliferation and metastasis in bladder cancer.
    Title: MicroRNA-186 suppresses cell proliferation and metastasis in bladder cancer.
  6. ADAMTS12 promotes migration and epithelial-mesenchymal transition and predicts poor prognosis for pancreatic cancer.
    Title: ADAMTS12 promotes migration and epithelial-mesenchymal transition and predicts poor prognosis for pancreatic cancer.
  7. Promoter Methylation of PRKCB, ADAMTS12, and NAALAD2 Is Specific to Prostate Cancer and Predicts Biochemical Disease Recurrence.
    Title: Promoter Methylation of PRKCB, ADAMTS12, and NAALAD2 Is Specific to Prostate Cancer and Predicts Biochemical Disease Recurrence.
  8. ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group.
    Title: ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.
  9. ADAMTS12 expression is significantly upregulated in human masticatory mucosa during wound healing
    Title: Human gingiva transcriptome during wound healing.
  10. Decreased levels of ADAMTS-12 were found to be associated with intrahepatic cholestasis of pregnancy.
    Title: Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.
EBI GWAS Catalog
Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced downregulation of ADAM metallopeptidase with thrombospondin type 1 motif, 12 (ADAMTS12) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to BMP stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in collagen fibril organization IEA
Inferred from Electronic Annotation
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of chondrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of hepatocyte growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ossification involved in bone maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteoglycan catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endothelial tube morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 12
Names
ADAM-TS 12
ADAM-TS12
ADAMTS-12
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324511.2 → NP_001311440.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform 2. The encoded isoform (2) lacks the furin cleavage site, a portion of the propeptide and most conserved domains compared to isoform 1.
    Source sequence(s)
    AC008880, BC139900, BG108002, BQ774480, N93301
    Consensus CDS
    CCDS87292.1
    UniProtKB/TrEMBL
    D6REX0
    Related
    ENSP00000421638.1, ENST00000515401.1
    Conserved Domains (1) summary
    pfam01562
    Location:53 → 195
    Pep_M12B_propep; Reprolysin family propeptide

  2. NM_001324512.2 → NP_001311441.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3. The encoded isoform (3) may undergo proteolytic processing.
    Source sequence(s)
    AC034232, BC131733, BG108002, CA413137
    Consensus CDS
    CCDS87293.1
    UniProtKB/Swiss-Prot
    P58397
    Related
    ENSP00000344847.3, ENST00000352040.7

  3. NM_030955.4 → NP_112217.2  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_112217.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC034232, AJ250725, AW938686, AY358745, BC058841, CA413137
    Consensus CDS
    CCDS34140.1
    UniProtKB/Swiss-Prot
    A2RRN9, A5D6V6, P58397, Q6UWL3
    Related
    ENSP00000422554.1, ENST00000504830.6
    Conserved Domains (6) summary
    smart00209
    Location:545 → 596
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:246 → 453
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:246 → 456
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:80 → 194
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:702 → 813
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:515 → 676
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    33523535..33891990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009905.2 → XP_016865394.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1

  2. XM_017009906.1 → XP_016865395.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X2

  3. XM_017009907.1 → XP_016865396.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X3

  4. XM_017009908.1 → XP_016865397.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X4

  5. XM_017009909.2 → XP_016865398.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187551.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    82443..93312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    33638143..34013900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353581.1 → XP_054209556.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1

  2. XM_054353582.1 → XP_054209557.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X2

  3. XM_054353583.1 → XP_054209558.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X3

  4. XM_054353584.1 → XP_054209559.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X4

  5. XM_054353585.1 → XP_054209560.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58397.2 GenPept UniProtKB/Swiss-Prot:P58397

Gene LinkOut

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