WDR55 transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: WDR55
Official Full Name: transducin family protein / WD-40 repeat family protein
Primary source: TAIR:AT2G34260
Locus tag: AT2G34260
See related: Araport:AT2G34260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F13P17.10; F13P17_10; human WDR55 (WD40 repeat) homolog
Summary: Encodes a WDxR motif-containing protein that is required for gametogenesis, seed and endosperm development.
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Genomic context

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See WDR55 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 14

Sequence:: Chromosome: 2; NC_003071.7 (14465516..14468547)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a DDB1(WDR55) complex could regulate embryo and endosperm development.[WDR55]
Title: The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development.
WDR55-DDB1 complex is involved in the establishment of bilateral symmetry in the Arabidopsis embryo.
Title: Arabidopsis WD repeat domain55 Interacts with DNA damaged binding protein1 and is required for apical patterning in the embryo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_128977.4

Supported by ESTs:

NM_201867.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of bilateral symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental vegetative growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo sac development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endosperm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within polar nucleus fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transducin family protein / WD-40 repeat family protein

NP_565782.1

transducin family protein / WD-40 repeat family protein; FUNCTIONS IN: nucleotide binding; LOCATED IN: CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), WD repeat protein 55 (InterPro:IPR017422), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT2G43770.1); Has 21772 Blast hits to 13043 proteins in 620 species: Archae - 50; Bacteria - 4645; Metazoa - 7300; Fungi - 4653; Plants - 2070; Viruses - 0; Other Eukaryotes - 3054 (source: NCBI BLink).

NP_973596.1

transducin family protein / WD-40 repeat family protein; FUNCTIONS IN: nucleotide binding; LOCATED IN: CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT3G49660.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

14465516..14468547

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128977.4 → NP_565782.1 transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565782.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4IGY3, O80775

UniProtKB/TrEMBL

A0A178VXX8, A0A5S9X3X8, A0A654EYQ8

Conserved Domains (2) summary

sd00039
Location:12 → 49

7WD40; WD40 repeat [structural motif]

cl29593
Location:12 → 290

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_201867.2 → NP_973596.1 transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_973596.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VXX8, A0A5S9X3X8

Conserved Domains (3) summary

COG2319
Location:9 → 245

WD40; WD40 repeat [General function prediction only]

sd00039
Location:41 → 75

7WD40; WD40 repeat [structural motif]

cl02567
Location:1 → 233

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...