Stx4 syntaxin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stx4provided by RGD
Official Full Name: syntaxin 4provided by RGD
Primary source: RGD:621019
See related: EnsemblRapid:ENSRNOG00000019302 AllianceGenome:RGD:621019
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Stx4a
Summary: Enables SNAP receptor activity; SNARE binding activity; and small GTPase binding activity. Involved in several processes, including exocytosis; membrane fusion; and protein localization to cell surface. Located in several cellular components, including basolateral plasma membrane; neuron projection membrane; and sarcolemma. Part of SNARE complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human STX4 (syntaxin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 114.1), Lung (RPKM 99.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191880549..191890333)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182451108..182459701)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199287384..199295606)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin-4 and CRACM3 interact in a non-excitable vesicle fusion.Extracellular loop 3 and the C-terminus of CRACM3 are critical for binding the N-peptide of syntaxin-4.
Title: CRACM3 regulates the stability of non-excitable exocytotic vesicle fusion pores in a Ca(2+)-independent manner via molecular interaction with syntaxin4.
Syntaxin-4 and SNAP23 act as exocytic soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) to release nerve growth factors from cultured Schwann cells.
Title: Syntaxin-4 and SNAP23 act as exocytic SNAREs to release NGF from cultured Schwann cells.
Our study uncovers the postsynaptic function of the SNAP25-VAMP1-syntaxin4 complex in mediating the constitutive exocytosis of NMDA receptors, suggesting that this SNARE complex is involved in excitatory synaptic transmission
Title: Identification of the SNARE complex mediating the exocytosis of NMDA receptors.
Syntaxin 1 was localized to the plasma membrane of the presynaptic terminal, including the active zone, while syntaxin 4 was localized to peri-synaptic astroglial processes. Results show that syntaxin 4 is available to support exocytosis in astroglia.
Title: Syntaxin 4 is concentrated on plasma membrane of astrocytes.
Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4.
Title: Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling.
These data suggest that Rab17 mediates the dendritic trafficking of Syntaxin-4 to selectively regulate dendritic surface insertion of GluK2-containing KARs in rat hippocampal neurons.
Title: Small GTPase Rab17 regulates the surface expression of kainate receptors but not α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hippocampal neurons via dendritic trafficking of Syntaxin-4 protein.
regulation of mucosal mast cell activation
Title: Regulation of mucosal mast cell activation by short interfering RNAs targeting syntaxin4.
Data showv that complexin 2 interacts with vesicle-associated membrane protein (VAMP) 2, syntaxins 3 and 4.
Title: Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini.
Syntaxin-4 and VAMP-1 and VAMP-2 regulate cardiac myocyte exocytosis of ANP.
Title: VAMP-1, VAMP-2, and syntaxin-4 regulate ANP release from cardiac myocytes.
Report interactions between syntaxin 4 and aquaporins in inner medullary collecting ducts.
Title: Syntaxin specificity of aquaporins in the inner medullary collecting duct.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IPI Inferred from Physical Interaction more info	PubMed
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sphingomyelin phosphodiesterase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SNARE complex assembly	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cornified envelope assembly	ISO Inferred from Sequence Orthology more info
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular transport	NAS Non-traceable Author Statement more info	PubMed
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in organelle fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of eosinophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle docking	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport in synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lateral loop	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in myelin sheath adaxonal region	ISO Inferred from Sequence Orthology more info
located_in neuron projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in somatodendritic compartment	ISO Inferred from Sequence Orthology more info
located_in specific granule	ISO Inferred from Sequence Orthology more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium	ISS Inferred from Sequence or Structural Similarity more info
located_in storage vacuole	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntaxin-4

Names: syntaxin 4A (placental)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031125.2 → NP_112387.2 syntaxin-4

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

G3V8I4, Q08850

Conserved Domains (3) summary

cd00179
Location:39 → 189

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

pfam05739
Location:236 → 287

SNARE; SNARE domain

cl22856
Location:199 → 260

SNARE; SNARE motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

191880549..191890333

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230345.5 → XP_006230407.1 syntaxin-4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZKM3

Related

ENSRNOP00000078300.1, ENSRNOT00000095917.2

Conserved Domains (3) summary

cd00179
Location:39 → 189

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15883
Location:199 → 260

SNARE_syntaxin4; SNARE motif of syntaxin 4

pfam00804
Location:39 → 235

Syntaxin; Syntaxin
XM_039092312.2 → XP_038948240.1 syntaxin-4 isoform X3

UniProtKB/TrEMBL

A0A8I5XA32, A6I9V1

Related

ENSRNOP00000026224.2, ENSRNOT00000026224.4

Conserved Domains (2) summary

cd00179
Location:39 → 189

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15883
Location:199 → 260

SNARE_syntaxin4; SNARE motif of syntaxin 4
XM_039092320.2 → XP_038948248.1 syntaxin-4 isoform X4

UniProtKB/Swiss-Prot

G3V8I4, Q08850

Conserved Domains (3) summary

cd00179
Location:39 → 189

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

pfam05739
Location:236 → 287

SNARE; SNARE domain

cl22856
Location:199 → 260

SNARE; SNARE motif
XM_006230348.5 → XP_006230410.1 syntaxin-4 isoform X5

Conserved Domains (3) summary

cd00179
Location:39 → 189

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

pfam00804
Location:39 → 234

Syntaxin; Syntaxin

cl22856
Location:199 → 234

SNARE; SNARE motif
XM_006230346.5 → XP_006230408.1 syntaxin-4 isoform X2

Conserved Domains (3) summary

cd00179
Location:1 → 138

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15883
Location:148 → 209

SNARE_syntaxin4; SNARE motif of syntaxin 4

pfam00804
Location:1 → 184

Syntaxin; Syntaxin