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SUVH5 SU(VAR)3-9 homolog 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818083, updated on 18-Sep-2024

Summary

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Official Symbol
SUVH5
Official Full Name
SU(VAR)3-9 homolog 5
Primary source
TAIR:AT2G35160
Locus tag
AT2G35160
See related
Araport:AT2G35160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
SET DOMAIN-CONTAINING PROTEIN 9; SGD9; SU(VAR)3-9 homolog 5; T4C15.17; T4C15_17
Summary
Encodes SU(var)3-9 homologue 5 (SUVH5). SUVH5 has histone methyltransferase (MTase) activity in vitro and contributes to the maintenance of H3 mK9 (methylation of histone H3 at Lys-9) and CMT3-mediated non-CG methylation in vivo. This is a member of a subfamily of SET proteins that shares a conserved SRA domain.
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Genomic context

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See SUVH5 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (14822774..14826194)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene EXORDIUM like 7 Neighboring gene Trypsin family protein Neighboring gene ncRNA Neighboring gene Histone H3 K4-specific methyltransferase SET7/9 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Rajakumara E, et al. Genes Dev, 2011 Jan 15. PMID 21245167, Free PMC Article
  2. Locus-specific control of DNA methylation by the Arabidopsis SUVH5 histone methyltransferase. Ebbs ML, et al. Plant Cell, 2006 May. PMID 16582009, Free PMC Article
  3. HISTONE DEACETYLASE6 Acts in Concert with Histone Methyltransferases SUVH4, SUVH5, and SUVH6 to Regulate Transposon Silencing. Yu CW, et al. Plant Cell, 2017 Aug. PMID 28778955, Free PMC Article
  4. The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes. Baumbusch LO, et al. Nucleic Acids Res, 2001 Nov 1. PMID 11691919, Free PMC Article
  5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the histone deacetylase HDA6 can interact with the histone methyltransferases SUVH4, SUVH5, and SUVH6 (SUVH4/5/6).
    Title: HISTONE DEACETYLASE6 Acts in Concert with Histone Methyltransferases SUVH4, SUVH5, and SUVH6 to Regulate Transposon Silencing.
  2. a functional SUVH5 SRA domain is required for both DNA methylation and accumulation of the H3K9 dimethyl modification in vivo, suggesting a role for the SRA domain in recruitment of SUVH5 to genomic loci.
    Title: A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo.
  3. SUVH5 protein has histone methyltransferase activity in vitro and contributes to the maintenance of methylation of histone H3 at Lysine-9 and CMT3-mediated non-CG methylation in vivo.
    Title: Locus-specific control of DNA methylation by the Arabidopsis SUVH5 histone methyltransferase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001336547.1
NM_001336548.1
NM_001336549.1
NM_001336550.1
NM_129070.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within epigenetic regulation of gene expression TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression via chromosomal CpG island methylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulatory ncRNA-mediated heterochromatin formation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of histone acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
SU(VAR)3-9 homolog 5
NP_181061.1
  • SU(VAR)3-9 homolog 5 (SUVH5); FUNCTIONS IN: histone methyltransferase activity; INVOLVED IN: maintenance of DNA methylation, histone methylation, regulation of gene expression, epigenetic, response to chitin, chromatin silencing by small RNA; LOCATED IN: nucleus; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), SRA-YDG (InterPro:IPR003105), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728), Post-SET domain (InterPro:IPR003616); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 6 (TAIR:AT2G22740.1); Has 5295 Blast hits to 5101 proteins in 461 species: Archae - 0; Bacteria - 388; Metazoa - 2414; Fungi - 548; Plants - 1120; Viruses - 0; Other Eukaryotes - 825 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    14822774..14826194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129070.3 → NP_181061.1  SU(VAR)3-9 homolog 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181061.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82175
    UniProtKB/TrEMBL
    A0A178VMZ6, A0A654EZ05
    Conserved Domains (2) summary
    smart00466
    Location:360 → 519
    SRA; SET and RING finger associated domain
    cl40432
    Location:565 → 765
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  2. NM_001336547.1 → NP_001324389.1  SU(VAR)3-9 homolog 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82175
    UniProtKB/TrEMBL
    A0A178VMZ6, A0A654EZ05
    Conserved Domains (2) summary
    smart00466
    Location:360 → 519
    SRA; SET and RING finger associated domain
    cl40432
    Location:565 → 765
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  3. NM_001336548.1 → NP_001324388.1  SU(VAR)3-9 homolog 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82175
    UniProtKB/TrEMBL
    A0A178VMZ6, A0A654EZ05
    Conserved Domains (2) summary
    smart00466
    Location:360 → 519
    SRA; SET and RING finger associated domain
    cl40432
    Location:565 → 765
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  4. NM_001336550.1 → NP_001324387.1  SU(VAR)3-9 homolog 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AZY9, A0A654EZ05

  5. NM_001336549.1 → NP_001324386.1  SU(VAR)3-9 homolog 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82175
    UniProtKB/TrEMBL
    A0A178VMZ6, A0A654EZ05
    Conserved Domains (2) summary
    smart00466
    Location:360 → 519
    SRA; SET and RING finger associated domain
    cl40432
    Location:565 → 765
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O82175.1

Gene LinkOut

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