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LOS2 Enolase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818226, updated on 18-Sep-2024

Summary

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Official Symbol
LOS2
Official Full Name
Enolase
Primary source
TAIR:AT2G36530
Locus tag
AT2G36530
See related
Araport:AT2G36530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
cytosolic enolase; ENO2; ENOC; ENOLASE 2; F1O11.16; F1O11_16; LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 2
Summary
Involved in light-dependent cold tolerance and encodes an enolase. Protein is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.
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Genomic context

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See LOS2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
12
Sequence:
Chromosome: 2; NC_003071.7 (15320756..15324129, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene tRNA-Leu Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene haloacid dehalogenase-like hydrolase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AtENO2 functions in the development of male gametophytes in Arabidopsis thaliana. Ma X, et al. J Plant Physiol, 2021 Aug. PMID 34102568
  2. ENO2 Affects the Seed Size and Weight by Adjusting Cytokinin Content and Forming ENO2-bZIP75 Complex in Arabidopsis thaliana. Liu Z, et al. Front Plant Sci, 2020. PMID 32983222, Free PMC Article
  3. LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolase. Lee H, et al. EMBO J, 2002 Jun 3. PMID 12032082, Free PMC Article
  4. Reduction of the canonical function of a glycolytic enzyme enolase triggers immune responses that further affect metabolism and growth in Arabidopsis. Yang L, et al. Plant Cell, 2022 Apr 26. PMID 34791448, Free PMC Article
  5. ENO2 activity is required for the development and reproductive success of plants, and is feedback-repressed by AtMBP-1. Eremina M, et al. Plant J, 2015 Mar. PMID 25620024

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In addition to an enolase the LOS2/ENO2 locus encodes the transcription factor AtMBP-1, and here we reveal that this bifunctionality serves to maintain the homeostasis of ENO2 activity.
    Title: ENO2 activity is required for the development and reproductive success of plants, and is feedback-repressed by AtMBP-1.
  2. MBP-1-like protein, like tumor suppressor c-myc binding protein, is alternatively translated from full-length LOS2 transcripts using a second start codon.
    Title: AtMBP-1, an alternative translation product of LOS2, affects abscisic acid responses and is modulated by the E3 ubiquitin ligase AtSAP5.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001336601.1
NM_129209.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion binding HDA PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphopyruvate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within glycolytic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphopyruvate hydratase complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
Enolase
NP_181192.1
  • LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 2 (LOS2); FUNCTIONS IN: phosphopyruvate hydratase activity, copper ion binding; INVOLVED IN: response to cadmium ion, response to salt stress, response to cold, response to light stimulus, response to abscisic acid stimulus; LOCATED IN: in 8 components; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Enolase (InterPro:IPR000941), Enolase, C-terminal (InterPro:IPR020810), Enolase, conserved site (InterPro:IPR020809), Enolase, N-terminal (InterPro:IPR020811); BEST Arabidopsis thaliana protein match is: enolase 1 (TAIR:AT1G74030.1); Has 13396 Blast hits to 13370 proteins in 3710 species: Archae - 270; Bacteria - 5735; Metazoa - 2292; Fungi - 281; Plants - 265; Viruses - 0; Other Eukaryotes - 4553 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    15320756..15324129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129209.4 → NP_181192.1  Enolase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181192.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25696, Q8RWM8, Q8VYG4, Q940N0
    UniProtKB/TrEMBL
    A0A178VT47, A0A5S9X4J0
    Conserved Domains (1) summary
    PLN00191
    Location:1 → 442
    PLN00191; enolase

  2. NM_001336601.1 → NP_001324936.1  Enolase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B1N1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25696.1

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