Neutral/alkaline non-lysosomal ceramidase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: Neutral/alkaline non-lysosomal ceramidase
Primary source: TAIR:AT2G38010
Locus tag: AT2G38010
See related: Araport:AT2G38010
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: T8P21.8; T8P21_8
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 8

Sequence:: Chromosome: 2; NC_003071.7 (15906555..15909931)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The acer-1 mutants and AtACER RNAi lines showed increased sensitivity to salt stress, and lines overexpressing AtACER showed increased tolerance to salt stress. Reduction of AtACER also increased plant susceptibility to Pseudomonas syringae.
Title: The Arabidopsis ceramidase AtACER functions in disease resistance and salt tolerance.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001336684.1

Supported by ESTs:

NM_129358.3

Supported by ESTs:

NM_201899.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables N-acylsphingosine amidohydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ceramide catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: Neutral/alkaline non-lysosomal ceramidase

NP_181337.2

Neutral/alkaline non-lysosomal ceramidase; FUNCTIONS IN: ceramidase activity; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Neutral/alkaline nonlysosomal ceramidase (InterPro:IPR006823); BEST Arabidopsis thaliana protein match is: Neutral/alkaline non-lysosomal ceramidase (TAIR:AT1G07380.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_973628.1

Neutral/alkaline non-lysosomal ceramidase; FUNCTIONS IN: ceramidase activity; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Neutral/alkaline nonlysosomal ceramidase (InterPro:IPR006823); BEST Arabidopsis thaliana protein match is: Neutral/alkaline non-lysosomal ceramidase (TAIR:AT1G07380.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

15906555..15909931

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_201899.2 → NP_973628.1 Neutral/alkaline non-lysosomal ceramidase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_973628.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q304B9

Conserved Domains (3) summary

PTZ00487
Location:26 → 773

PTZ00487; ceramidase; Provisional

pfam04734
Location:26 → 626

Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal

pfam17048
Location:628 → 775

Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
NM_001336684.1 → NP_001324325.1 Neutral/alkaline non-lysosomal ceramidase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VXV8, A0A1P8AZR2, A0A384KP75

Conserved Domains (2) summary

pfam04734
Location:26 → 591

Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal

pfam17048
Location:593 → 740

Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
NM_129358.3 → NP_181337.2 Neutral/alkaline non-lysosomal ceramidase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181337.2

Status: REVIEWED

UniProtKB/Swiss-Prot

F4IRY2, Q304B9, Q3EBK8, Q7XJQ9

Conserved Domains (3) summary

PTZ00487
Location:26 → 738

PTZ00487; ceramidase; Provisional

pfam04734
Location:26 → 591

Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal

pfam17048
Location:593 → 740

Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal