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PP2C5 phosphatase 2C5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818609, updated on 18-Sep-2024

Summary

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Official Symbol
PP2C5
Official Full Name
phosphatase 2C5
Primary source
TAIR:AT2G40180
Locus tag
AT2G40180
See related
Araport:AT2G40180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATHPP2C5; phosphatase 2C5; T7M7.17
Summary
Encodes PP2C5, a member of the PP2C family phosphatases. PP2C5 acts as a MAPK phosphatase that positively regulates seed germination, stomatal closure and ABA-inducible gene expression.
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Genomic context

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See PP2C5 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (16782366..16784147)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene trichome birefringence-like protein (DUF828) Neighboring gene Stress induced protein Neighboring gene UDP-Glycosyltransferase superfamily protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Ribosomal protein L41 family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MAPK phosphatase AP2C3 induces ectopic proliferation of epidermal cells leading to stomata development in Arabidopsis. Umbrasaite J, et al. PLoS One, 2010 Dec 23. PMID 21203456, Free PMC Article
  2. Bimolecular fluorescent complementation (BiFC) by MAP kinases and MAPK phosphatases. Schweighofer A, et al. Methods Mol Biol, 2014. PMID 24908126
  3. The Arabidopsis mitogen-activated protein kinase phosphatase PP2C5 affects seed germination, stomatal aperture, and abscisic acid-inducible gene expression. Brock AK, et al. Plant Physiol, 2010 Jul. PMID 20488890, Free PMC Article
  4. A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Lalonde S, et al. Front Physiol, 2010. PMID 21423366, Free PMC Article
  5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PP2C5 acts as a mitogen-activated protein kinases phosphatase that positively regulates seed germination, stomatal closure, and ABA-inducible gene expression. [PP2C5]
    Title: The Arabidopsis mitogen-activated protein kinase phosphatase PP2C5 affects seed germination, stomatal aperture, and abscisic acid-inducible gene expression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_129576.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stomatal lineage progression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatase 2C5
NP_181547.1
  • phosphatase 2C5 (PP2C5); CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT1G07160.1); Has 6862 Blast hits to 6800 proteins in 519 species: Archae - 10; Bacteria - 469; Metazoa - 1632; Fungi - 782; Plants - 2690; Viruses - 9; Other Eukaryotes - 1270 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    16782366..16784147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129576.3 → NP_181547.1  phosphatase 2C5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181547.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q84K48, Q9XEE8
    UniProtKB/TrEMBL
    A0A178VQY5, A0A5S9X5N9, A0A654F1T1, F6LPR7
    Conserved Domains (1) summary
    cd00143
    Location:128 → 385
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XEE8.1

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