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BHLH100 basic helix-loop-helix protein 100 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818723, updated on 18-Sep-2024

Summary

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Official Symbol
BHLH100
Official Full Name
basic helix-loop-helix protein 100
Primary source
TAIR:AT2G41240
Locus tag
AT2G41240
See related
Araport:AT2G41240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
basic helix-loop-helix protein 100; F13H10.21; F13H10_21
Summary
Encodes a member of the basic helix-loop-helix transcription factor family protein. Functions as a key regulator of iron-deficiency responses independent of the master regulator FIT. Likely regulates genes involved in the distribution of iron within the plant.
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Genomic context

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See BHLH100 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
2
Sequence:
Chromosome: 2; NC_003071.7 (17198037..17199454, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ORGAN SIZE-like protein Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene glycine-rich protein / late embryogenesis abundant protein (M17)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Iron deficiency-induced transcription factors bHLH38/100/101 negatively modulate flowering time in Arabidopsis thaliana. Chen W, et al. Plant Sci, 2021 Jul. PMID 34034877
  2. Arabidopsis bHLH100 and bHLH101 control iron homeostasis via a FIT-independent pathway. Sivitz AB, et al. PLoS One, 2012. PMID 22984573, Free PMC Article
  3. Iron deficiency-mediated stress regulation of four subgroup Ib BHLH genes in Arabidopsis thaliana. Wang HY, et al. Planta, 2007 Sep. PMID 17516080
  4. Requirement and functional redundancy of Ib subgroup bHLH proteins for iron deficiency responses and uptake in Arabidopsis thaliana. Wang N, et al. Mol Plant, 2013 Mar. PMID 22983953
  5. The relationship of drought-related gene expression in Arabidopsis thaliana to hormonal and environmental factors. Huang D, et al. J Exp Bot, 2008. PMID 18552355, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Iron deficiency-induced transcription factors bHLH38/100/101 negatively modulate flowering time in Arabidopsis thaliana.
    Title: Iron deficiency-induced transcription factors bHLH38/100/101 negatively modulate flowering time in Arabidopsis thaliana.
  2. bHLH100 and bHLH101 are key regulators of iron-deficiency responses independent of the master regulator FIT
    Title: Arabidopsis bHLH100 and bHLH101 control iron homeostasis via a FIT-independent pathway.
  3. up-regulated by iron deficiency in roots and leaves
    Title: Iron deficiency-mediated stress regulation of four subgroup Ib BHLH genes in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_129689.2
NM_180018.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to iron ion starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
basic helix-loop-helix protein 100
NP_181657.1
  • basic helix-loop-helix protein 100 (BHLH100); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to water deprivation, regulation of transcription; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: Achaete-scute transcription factor related (InterPro:IPR015660), Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT3G56970.1); Has 1014 Blast hits to 1014 proteins in 111 species: Archae - 0; Bacteria - 2; Metazoa - 217; Fungi - 10; Plants - 760; Viruses - 12; Other Eukaryotes - 13 (source: NCBI BLink).
NP_850349.1
  • basic helix-loop-helix protein 100 (BHLH100); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to water deprivation, regulation of transcription; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: Achaete-scute transcription factor related (InterPro:IPR015660), Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT3G56970.1); Has 850 Blast hits to 850 proteins in 99 species: Archae - 0; Bacteria - 2; Metazoa - 130; Fungi - 33; Plants - 678; Viruses - 0; Other Eukaryotes - 7 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    17198037..17199454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129689.2 → NP_181657.1  basic helix-loop-helix protein 100 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181657.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3E7M6, Q9ZVB5
    UniProtKB/TrEMBL
    A0A178VX33, A0A384LFW4, C0SV82
    Conserved Domains (1) summary
    cd18914
    Location:62 → 136
    bHLH_AtORG2_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 (ORG2), 3 (ORG3) and similar proteins

  2. NM_180018.1 → NP_850349.1  basic helix-loop-helix protein 100 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850349.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9ZVB5
    Conserved Domains (1) summary
    pfam00010
    Location:62 → 113
    HLH; Helix-loop-helix DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZVB5.1

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