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ncoa2 nuclear receptor coactivator 2 [ Danio rerio (zebrafish) ]

Gene ID: 81884, updated on 4-Jan-2025

Summary

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Official Symbol
ncoa2provided by ZNC
Official Full Name
nuclear receptor coactivator 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-010406-3
See related
Ensembl:ENSDARG00000017929 AllianceGenome:ZFIN:ZDB-GENE-010406-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tif2; wu:fc41a10; wu:fe26a11
Summary
Enables nuclear thyroid hormone receptor binding activity. Involved in granulocyte differentiation and primitive hemopoiesis. Acts upstream of or within chordate embryonic development. Predicted to be active in nucleus. Is expressed in several structures, including eye; gill; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; lung non-small cell carcinoma; and prostate adenocarcinoma. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ncoa2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (14237944..14444945)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (14093413..14300526)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene XK, Kell blood group complex subunit-related family, member 9 Neighboring gene translocation associated membrane protein 1 Neighboring gene uncharacterized LOC137489222 Neighboring gene PR domain containing 14 Neighboring gene putative nuclease HARBI1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cloning, genomic organization, and expression analysis of zebrafish nuclear receptor coactivator, TIF2. Tan JH, et al. Zebrafish, 2005. PMID 18248177
  2. An F-domain introduced by alternative splicing regulates activity of the zebrafish thyroid hormone receptor alpha. Takayama S, et al. Gen Comp Endocrinol, 2008 Jan 1. PMID 17583703, Free PMC Article
  3. Co-option of the PRDM14-CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Kawaguchi M, et al. Development, 2019 Jan 28. PMID 30630825
  4. A role for the transcription intermediary factor 2 in zebrafish myelopoiesis. Zhuravleva J, et al. Exp Hematol, 2008 May. PMID 18295965
  5. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. McGrail M, et al. PLoS One, 2011 Apr 21. PMID 21533036, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nuclear thyroid hormone receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within primitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in primitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nuclear receptor coactivator 2
Names
grip1
src2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131777.1 → NP_571852.1  nuclear receptor coactivator 2

    See identical proteins and their annotated locations for NP_571852.1

    Status: PROVISIONAL

    Source sequence(s)
    AF323989
    UniProtKB/Swiss-Prot
    B3DK53, Q98TW1
    Related
    ENSDARP00000107210.2, ENSDART00000124740.4
    Conserved Domains (8) summary
    smart00353
    Location:36 → 89
    HLH; helix loop helix domain
    smart00091
    Location:119 → 176
    PAS; PAS domain
    pfam07469
    Location:1354 → 1410
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1061 → 1106
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:629 → 705
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:267 → 375
    PAS_11; PAS domain
    pfam16279
    Location:728 → 803
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:460 → 567
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    14237944..14444945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009297336.4 → XP_009295611.1  nuclear receptor coactivator 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AP61, E7F5J8
    Related
    ENSDARP00000157542.1, ENSDART00000182279.1
    Conserved Domains (8) summary
    smart00353
    Location:36 → 89
    HLH; helix loop helix domain
    smart00091
    Location:119 → 176
    PAS; PAS domain
    pfam07469
    Location:1354 → 1410
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1061 → 1106
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:629 → 705
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:267 → 375
    PAS_11; PAS domain
    pfam16279
    Location:728 → 803
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:460 → 567
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  2. XM_021470228.2 → XP_021325903.1  nuclear receptor coactivator 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PG56
    Conserved Domains (9) summary
    smart00353
    Location:36 → 89
    HLH; helix loop helix domain
    smart00091
    Location:119 → 176
    PAS; PAS domain
    pfam07469
    Location:1354 → 1410
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1061 → 1106
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:629 → 705
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:880 → 1218
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:267 → 375
    PAS_11; PAS domain
    pfam16279
    Location:728 → 803
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:460 → 558
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  3. XM_009297338.4 → XP_009295613.1  nuclear receptor coactivator 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AZ20, F6NH98
    Related
    ENSDARP00000109306.2, ENSDART00000124181.4
    Conserved Domains (8) summary
    smart00353
    Location:36 → 89
    HLH; helix loop helix domain
    smart00091
    Location:119 → 176
    PAS; PAS domain
    pfam07469
    Location:1289 → 1340
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1061 → 1106
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:629 → 705
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:267 → 375
    PAS_11; PAS domain
    pfam16279
    Location:728 → 803
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:460 → 567
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  4. XM_068217125.1 → XP_068073226.1  nuclear receptor coactivator 2 isoform X4

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395168.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    250028..353232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q98TW1.1 GenPept UniProtKB/Swiss-Prot:Q98TW1

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