Nucleotidyltransferase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: Nucleotidyltransferase family protein
Primary source: TAIR:AT2G45620
Locus tag: AT2G45620
See related: Araport:AT2G45620
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F17K2.15; URT1; UTP:RNA uridylyltransferase 1
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 6

Sequence:: Chromosome: 2; NC_003071.7 (18792864..18795904)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular mechanism underlying the di-uridylation activity of Arabidopsis TUTase URT1.
Title: Molecular mechanism underlying the di-uridylation activity of Arabidopsis TUTase URT1.
The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis.
Title: The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis.
Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
Title: Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
role in RNA metabolism and silencing
Title: A genetics screen highlights emerging roles for CPL3, RST1 and URT1 in RNA metabolism and silencing.
URT1 uridylates deadenylated mRNAs and prevents excessive deadenylation.
Title: Uridylation prevents 3' trimming of oligoadenylated mRNAs.
Results uncover a role for uridylation and PABP in repairing mRNA deadenylated ends and reveal that uridylation plays diverse roles in eukaryotic mRNA metabolism.
Title: Uridylation and PABP Cooperate to Repair mRNA Deadenylated Ends in Arabidopsis.
UTP: RNA uridylyltransferase (URT1) is a functional paralog of HESO1. URT1 interacts with AGO1 and plays a predominant role in miRNA uridylation when HESO1 is absent. [URT1]
Title: Synergistic and independent actions of multiple terminal nucleotidyl transferases in the 3' tailing of small RNAs in Arabidopsis.
URT1 and HESO1 prefer substrates with different 3' end nucleotides in vitro and act cooperatively to tail different forms of the same miRNAs in vivo. Moreover, both HESO1 and URT1 exhibit nucleotidyl transferase activity on AGO1-bound miRNAs. [URT1]
Title: Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_130124.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA uridylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA 3' uridylation	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA 3' uridylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of post-transcriptional gene silencing by regulatory ncRNA	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Nucleotidyltransferase family protein

NP_566048.1

Nucleotidyltransferase family protein; FUNCTIONS IN: nucleotidyltransferase activity; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Nucleotidyl transferase domain (InterPro:IPR002934), PAP/25A-associated (InterPro:IPR002058); BEST Arabidopsis thaliana protein match is: Nucleotidyltransferase family protein (TAIR:AT3G45750.1); Has 1962 Blast hits to 1846 proteins in 232 species: Archae - 0; Bacteria - 9; Metazoa - 921; Fungi - 372; Plants - 185; Viruses - 0; Other Eukaryotes - 475 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18792864..18795904

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130124.1 → NP_566048.1 Nucleotidyltransferase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566048.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O64642, Q9C5K9

UniProtKB/TrEMBL

A0A5S9X7J0, A0A654F3F9

Conserved Domains (2) summary

cd05402
Location:456 → 566

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

pfam03828
Location:655 → 714

PAP_assoc; Cid1 family poly A polymerase