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CRF5 cytokinin response factor 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819239, updated on 18-Sep-2024

Summary

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Official Symbol
CRF5
Official Full Name
cytokinin response factor 5
Primary source
TAIR:AT2G46310
Locus tag
AT2G46310
See related
Araport:AT2G46310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
cytokinin response factor 5; T3F17.4
Summary
CRF5 encodes one of the six cytokinin response factors. It is transcriptionally upregulated in response to cytokinin. CRF5 belongs to the AP2/ERF superfamily of the transcriptional factors. CRF proteins rapidly relocalize to the nucleus in response to cytokinin. Analysis of loos-of-function mutants revealed that the CRFs function redundantly to regulate the development of embryos, cotyledons and leaves.
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Genomic context

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See CRF5 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
1
Sequence:
Chromosome: 2; NC_003071.7 (19011462..19013018)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene arabinogalactan protein 16

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A subset of Arabidopsis AP2 transcription factors mediates cytokinin responses in concert with a two-component pathway. Rashotte AM, et al. Proc Natl Acad Sci U S A, 2006 Jul 18. PMID 16832061, Free PMC Article
  2. CRFs form protein-protein interactions with each other and with members of the cytokinin signalling pathway in Arabidopsis via the CRF domain. Cutcliffe JW, et al. J Exp Bot, 2011 Oct. PMID 21705390, Free PMC Article
  3. A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis. Smit ME, et al. Plant Cell, 2020 Feb. PMID 31806676, Free PMC Article
  4. Transcriptional regulation of nitrogen-associated metabolism and growth. Gaudinier A, et al. Nature, 2018 Nov. PMID 30356219
  5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_130194.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cotyledon development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within leaf development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
cytokinin response factor 5
NP_182154.1
  • cytokinin response factor 5 (CRF5); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: cytokinin response factor 6 (TAIR:AT3G61630.1); Has 5622 Blast hits to 5574 proteins in 244 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 5609; Viruses - 2; Other Eukaryotes - 11 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    19011462..19013018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130194.5 → NP_182154.1  cytokinin response factor 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_182154.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82339
    UniProtKB/TrEMBL
    A0A5S9X7G6, A0A654F2F6
    Conserved Domains (1) summary
    smart00380
    Location:98 → 154
    AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O82339.1

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