U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ALG3 asparagine-linked glycosylation 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819388, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ALG3
Official Full Name
asparagine-linked glycosylation 3
Primary source
TAIR:AT2G47760
Locus tag
AT2G47760
See related
Araport:AT2G47760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis thaliana asparagine-linked glycosylation 3; asparagine-linked glycosylation 3; AtALG3; F17A22.15
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ALG3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
14
Sequence:
Chromosome: 2; NC_003071.7 (19564795..19568438, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene putative indole-3-acetic acid-amido synthetase GH3.9 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TSPO(outer membrane tryptophan-rich sensory protein)-like protein Neighboring gene Rubber elongation factor protein (REF) Neighboring gene Transducin/WD40 repeat-like superfamily protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Altered glycosylation of exported proteins, including surface immune receptors, compromises calcium and downstream signaling responses to microbe-associated molecular patterns in Arabidopsis thaliana. Trempel F, et al. BMC Plant Biol, 2016 Jan 28. PMID 26822404, Free PMC Article
  2. Arabidopsis thaliana ALG3 mutant synthesizes immature oligosaccharides in the ER and accumulates unique N-glycans. Kajiura H, et al. Glycobiology, 2010 Jun. PMID 20356820
  3. Identification of the gene encoding the alpha1,3-mannosyltransferase (ALG3) in Arabidopsis and characterization of downstream n-glycan processing. Henquet M, et al. Plant Cell, 2008 Jun. PMID 18567790, Free PMC Article
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. allelic cce2 and cce3 mutants are caused by mutations in AtALG3 (Asparagine-Linked Glycosylation 3), thereby resulting in underglycosylation of several PRRs and compromised MAMP/DAMP signaling
    Title: Altered glycosylation of exported proteins, including surface immune receptors, compromises calcium and downstream signaling responses to microbe-associated molecular patterns in Arabidopsis thaliana.
  2. In ALG3 mutant, an immature lipid-linked oligosaccharide structure,ER, was synthesized, and used for protein N-glycosylation, resulting in the blockade of subsequent maturation with the concanavalin A affinoactive and Endo H-insensitive structure.
    Title: Arabidopsis thaliana ALG3 mutant synthesizes immature oligosaccharides in the ER and accumulates unique N-glycans.
  3. ALG3 mutant analysis reveals that when ALG3 activity is strongly reduced, almost all N-glycans transferred to proteins are aberrant, indicating that the Arabidopsis oligosaccharide transferase complex is remarkably substrate tolerant.
    Title: Identification of the gene encoding the alpha1,3-mannosyltransferase (ALG3) in Arabidopsis and characterization of downstream n-glycan processing.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help
NM_001036479.1
NM_001036480.1
NM_001337274.1
NM_001337275.1
NM_130343.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables alpha-1,3-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mannosylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
asparagine-linked glycosylation 3
NP_001031556.1
  • asparagine-linked glycosylation 3 (ALG3); CONTAINS InterPro DOMAIN/s: Glycosyltransferase, ALG3 (InterPro:IPR007873); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001031557.1
  • asparagine-linked glycosylation 3 (ALG3); CONTAINS InterPro DOMAIN/s: Glycosyltransferase, ALG3 (InterPro:IPR007873); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001318442.1
  • asparagine-linked glycosylation 3 (ALG3); CONTAINS InterPro DOMAIN/s: Glycosyltransferase, ALG3 (InterPro:IPR007873); Has 381 Blast hits to 338 proteins in 173 species: Archae - 2; Bacteria - 2; Metazoa - 149; Fungi - 152; Plants - 35; Viruses - 0; Other Eukaryotes - 41 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    19564795..19568438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001337274.1 → NP_001318442.1  asparagine-linked glycosylation 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2H1ZE55, A0A5S9X8N8

  2. NM_001337275.1 → NP_001324356.1  asparagine-linked glycosylation 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AZV0, A0A5S9X8N8

  3. NM_001036479.1 → NP_001031556.1  asparagine-linked glycosylation 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031556.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VPN0
    Conserved Domains (1) summary
    pfam05208
    Location:37 → 400
    ALG3; ALG3 protein

  4. NM_001036480.1 → NP_001031557.1  asparagine-linked glycosylation 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031557.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9X8N8
    Conserved Domains (1) summary
    pfam05208
    Location:37 → 380
    ALG3; ALG3 protein

  5. NM_130343.4 → NP_182297.1  asparagine-linked glycosylation 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_182297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IM37, F4IM39, O82244, Q944H6
    UniProtKB/TrEMBL
    A0A178VPN0, W8Q394
    Conserved Domains (1) summary
    pfam05208
    Location:37 → 401
    ALG3; ALG3 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O82244.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.