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DEG2 DEGP protease 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819406, updated on 18-Sep-2024

Summary

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Official Symbol
DEG2
Official Full Name
DEGP protease 2
Primary source
TAIR:AT2G47940
Locus tag
AT2G47940
See related
Araport:AT2G47940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DEGP protease 2; DEGP2; degradation of periplasmic proteins 2; EMB3117; EMBRYO DEFECTIVE 3117
Summary
Encodes DegP2 protease (DEGP2); nuclear gene for chloroplast product.
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Genomic context

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See DEG2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
19
Sequence:
Chromosome: 2; NC_003071.7 (19617986..19622301, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene uncharacterized protein Neighboring gene arabinogalactan protein 26 Neighboring gene miscRNA Neighboring gene myelin transcription factor-like protein Neighboring gene trafficking protein particle complex subunit-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Photodamaged D1 protein is degraded in Arabidopsis mutants lacking the Deg2 protease. Huesgen PF, et al. FEBS Lett, 2006 Dec 22. PMID 17157840
  2. A chloroplast DegP2 protease performs the primary cleavage of the photodamaged D1 protein in plant photosystem II. Haussühl K, et al. EMBO J, 2001 Feb 15. PMID 11179216, Free PMC Article
  3. The thylakoid protease Deg2 is involved in stress-related degradation of the photosystem II light-harvesting protein Lhcb6 in Arabidopsis thaliana. Luciński R, et al. New Phytol, 2011 Oct. PMID 21668884
  4. A critical role for the Var2 FtsH homologue of Arabidopsis thaliana in the photosystem II repair cycle in vivo. Bailey S, et al. J Biol Chem, 2002 Jan 18. PMID 11717304
  5. Crystal structure of Arabidopsis Deg2 protein reveals an internal PDZ ligand locking the hexameric resting state. Sun R, et al. J Biol Chem, 2012 Oct 26. PMID 22961982, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structure of a conserved internal ligand of deg2 that mediates hexamer formation and locks the protease in the resting state.
    Title: Crystal structure of Arabidopsis Deg2 protein reveals an internal PDZ ligand locking the hexameric resting state.
  2. Deg2 is required for normal plant development, including the chloroplast life cycle, and has an important function in the degradation of Lhcb6 in response to short-duration stresses.
    Title: The thylakoid protease Deg2 is involved in stress-related degradation of the photosystem II light-harvesting protein Lhcb6 in Arabidopsis thaliana.
  3. rate of D1 protein degradation under light stress conditions in Arabidopsis mutants lacking the Deg2 protease is similar to those in wild-type plants. [Deg2]
    Title: Photodamaged D1 protein is degraded in Arabidopsis mutants lacking the Deg2 protease.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001125072.1
NM_130361.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloroplast organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photosystem II repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in chloroplast stromal thylakoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast thylakoid membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DEGP protease 2
NP_001118544.1
  • DEGP protease 2 (DEGP2); FUNCTIONS IN: serine-type peptidase activity, serine-type endopeptidase activity; INVOLVED IN: photosystem II repair, proteolysis; LOCATED IN: chloroplast stromal thylakoid, chloroplast thylakoid membrane, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Serine endopeptidase DegP2 (InterPro:IPR015724), Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003), Peptidase S1C, HrtA/DegP2/Q/S (InterPro:IPR001940), Peptidase S1/S6, chymotrypsin/Hap (InterPro:IPR001254), PDZ/DHR/GLGF (InterPro:IPR001478); BEST Arabidopsis thaliana protein match is: DegP protease 9 (TAIR:AT5G40200.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_566115.1
  • DEGP protease 2 (DEGP2); FUNCTIONS IN: serine-type peptidase activity, serine-type endopeptidase activity; INVOLVED IN: photosystem II repair, proteolysis; LOCATED IN: chloroplast stromal thylakoid, chloroplast thylakoid membrane, chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003), Serine endopeptidase DegP2 (InterPro:IPR015724), Peptidase S1C, HrtA/DegP2/Q/S (InterPro:IPR001940), Peptidase S1/S6, chymotrypsin/Hap (InterPro:IPR001254), PDZ/DHR/GLGF (InterPro:IPR001478); BEST Arabidopsis thaliana protein match is: DegP protease 9 (TAIR:AT5G40200.1); Has 15046 Blast hits to 15035 proteins in 2533 species: Archae - 101; Bacteria - 10614; Metazoa - 317; Fungi - 14; Plants - 376; Viruses - 0; Other Eukaryotes - 3624 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    19617986..19622301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130361.5 → NP_566115.1  DEGP protease 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566115.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82261, Q9FPE9
    UniProtKB/TrEMBL
    A0A178VUR8, A0A5S9X8G7
    Conserved Domains (2) summary
    TIGR02037
    Location:135 → 458
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    pfam17815
    Location:429 → 570
    PDZ_3; PDZ domain

  2. NM_001125072.1 → NP_001118544.1  DEGP protease 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3H581
    Conserved Domains (3) summary
    cd00987
    Location:320 → 419
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam00089
    Location:123 → 307
    Trypsin; Trypsin
    pfam13365
    Location:143 → 281
    Trypsin_2; Trypsin-like peptidase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O82261.2

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