GPX4 glutathione peroxidase 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GPX4
Official Full Name: glutathione peroxidase 4
Primary source: TAIR:AT2G48150
Locus tag: AT2G48150
See related: Araport:AT2G48150
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGPX4; F11L15.5; glutathione peroxidase 4
Summary: Encodes glutathione peroxidase.
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Genomic context

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See GPX4 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 6

Sequence:: Chromosome: 2; NC_003071.7 (19687831..19689229, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_001337302.1

Supported by ESTs:

NM_130382.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutathione peroxidase 4

NP_566128.1

glutathione peroxidase 4 (GPX4); FUNCTIONS IN: glutathione peroxidase activity; INVOLVED IN: oxidation reduction, response to oxidative stress, N-terminal protein myristoylation; LOCATED IN: cytosol; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like fold (InterPro:IPR012336), Glutathione peroxidase (InterPro:IPR000889); BEST Arabidopsis thaliana protein match is: glutathione peroxidase 5 (TAIR:AT3G63080.1); Has 7346 Blast hits to 7345 proteins in 1724 species: Archae - 2; Bacteria - 3554; Metazoa - 785; Fungi - 210; Plants - 383; Viruses - 8; Other Eukaryotes - 2404 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

19687831..19689229 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130382.2 → NP_566128.1 glutathione peroxidase 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566128.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L910

UniProtKB/TrEMBL

A0A178VXC8, A0A5S9X803

Conserved Domains (1) summary

cd00340
Location:11 → 163

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
NM_001337302.1 → NP_001324284.1 glutathione peroxidase 4 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AZN1