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Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819577, updated on 18-Sep-2024

Summary

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Official Full Name
Disease resistance protein (TIR-NBS-LRR class) family
Primary source
TAIR:AT3G04220
Locus tag
AT3G04220
See related
Araport:AT3G04220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
T6K12.16; T6K12_16
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Genomic context

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Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (1108725..1112437, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RmlC-like cupins superfamily protein Neighboring gene Disease resistance protein (TIR-NBS class) Neighboring gene ncRNA Neighboring gene Ribosomal protein S5 domain 2-like superfamily protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Function of miR825 and miR825* as Negative Regulators in Bacillus cereus AR156-elicited Systemic Resistance to Botrytis cinerea in Arabidopsis thaliana. Nie P, et al. Int J Mol Sci, 2019 Oct 11. PMID 31614458, Free PMC Article
  2. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

General gene information

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NM_111293.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ADP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Disease resistance protein (TIR-NBS-LRR class) family
NP_187072.2
  • Disease resistance protein (TIR-NBS-LRR class) family; FUNCTIONS IN: transmembrane receptor activity, nucleoside-triphosphatase activity, nucleotide binding, ATP binding; INVOLVED IN: signal transduction, defense response, apoptosis, innate immune response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) (TAIR:AT5G11250.1); Has 57565 Blast hits to 26212 proteins in 923 species: Archae - 48; Bacteria - 2396; Metazoa - 5228; Fungi - 257; Plants - 46915; Viruses - 16; Other Eukaryotes - 2705 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    1108725..1112437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001337508.1 → NP_001326120.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VAL8, Q9M8X8

  2. NM_001337507.1 → NP_001326119.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VAL8, A0A1I9LNB0

  3. NM_111293.2 → NP_187072.2  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187072.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VAL8, F4J3L8
    Conserved Domains (6) summary
    cd00009
    Location:241 → 381
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cd09293
    Location:668 → 845
    AMN1; Antagonist of mitotic exit network protein 1
    smart00382
    Location:259 → 392
    AAA; ATPases associated with a variety of cellular activities
    sd00033
    Location:631 → 656
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:63 → 228
    TIR; TIR domain
    pfam13855
    Location:787 → 845
    LRR_8; Leucine rich repeat
Nucleotide Protein
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