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PLDP2 phospholipase D P2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819730, updated on 18-Sep-2024

Summary

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Official Symbol
PLDP2
Official Full Name
phospholipase D P2
Primary source
TAIR:AT3G05630
Locus tag
AT3G05630
See related
Araport:AT3G05630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F18C1.10; F18C1_10; PDLZ2; PHOSPHOLIPASE D; phospholipase D P2; PHOSPHOLIPASE D ZETA 2; PLDZETA2
Summary
Encodes a member of the PXPH-PLD subfamily of phospholipase D proteins. Regulates vesicle trafficking. Required for auxin transport and distribution and hence auxin responses. This subfamily is novel structurally different from the majority of plant PLDs by having phox homology (PX) and pleckstrin homology (PH) domains. Involved regulating root development in response to nutrient limitation. Plays a major role in phosphatidic acid production during phosphate deprivation. Induced upon Pi starvation in both shoots and roots. Involved in hydrolyzing phosphatidylcholine and phosphatidylethanolamine to produce diacylglycerol for digalactosyldiacylglycerol synthesis and free Pi to sustain other Pi-requiring processes. Does not appear to be involved in root hair patterning. Expression is upregulated in the shoot of cax1/cax3 mutant.
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Genomic context

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See PLDP2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
16
Sequence:
Chromosome: 3; NC_003074.8 (1635194..1640357)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Protein phosphatase 2C family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene receptor like protein 32

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of the Arabidopsis PLDZ2 promoter reveals an evolutionarily conserved low-Pi-responsive transcriptional enhancer element. Oropeza-Aburto A, et al. J Exp Bot, 2012 Mar. PMID 22210906, Free PMC Article
  2. Involvement of Arabidopsis thaliana phospholipase Dzeta2 in root hydrotropism through the suppression of root gravitropism. Taniguchi YY, et al. Planta, 2010 Jan. PMID 19915862
  3. Phosphate availability affects the tonoplast localization of PLDzeta2, an Arabidopsis thaliana phospholipase D. Yamaryo Y, et al. FEBS Lett, 2008 Mar 5. PMID 18242181
  4. Arabidopsis PLDζ1 and PLDζ2 localize to post-Golgi membrane compartments in a partially overlapping manner. Shimamura R, et al. Plant Mol Biol, 2022 Jan. PMID 34601701
  5. Phospholipases AtPLDζ1 and AtPLDζ2 function differently in hypoxia. Lindberg S, et al. Physiol Plant, 2018 Jan. PMID 28834646

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis PLDzeta1 and PLDzeta2 localize to post-Golgi membrane compartments in a partially overlapping manner.
    Title: Arabidopsis PLDζ1 and PLDζ2 localize to post-Golgi membrane compartments in a partially overlapping manner.
  2. The efficiency of photosystem II, estimated by measuring the ratio of chlorophyll fluorescence (F v/ m ratio), was strongly decreased in pldzeta1 under salt stress. In conclusion, PLDzeta2 plays a key role in determining Arabidopsis sensitivity to salt stress allowing ion transport and antioxidant responses to be finely regulated.
    Title: Phospholipases Dζ1 and Dζ2 have distinct roles in growth and antioxidant systems in Arabidopsis thaliana responding to salt stress.
  3. AtPLDzeta2 is involved in phosphatidic acids production by a calcium signaling pathway, while AtPLDzeta1 is more important in reactive oxygen species signaling.
    Title: Phospholipases AtPLDζ1 and AtPLDζ2 function differently in hypoxia.
  4. A transcriptional enhancer is present in the PLDZ2 promoter and able to confer Pi responsiveness to a minimal, inactive 35S promoter. This enhancer also shares the cytokinin and sucrose responsive properties observed for the intact PLDZ2 promoter.
    Title: Functional analysis of the Arabidopsis PLDZ2 promoter reveals an evolutionarily conserved low-Pi-responsive transcriptional enhancer element.
  5. A variant of the PHR1 binding site is highly enriched in the Arabidopsis phosphate-responsive phospholipase DZ2 coexpression network.
    Title: A specific variant of the PHR1 binding site is highly enriched in the Arabidopsis phosphate-responsive phospholipase DZ2 coexpression network.
  6. PLDzeta2 responds to drought through ABA signaling in the root cap and accelerates root hydrotropism through the suppression of root gravitropism.
    Title: Involvement of Arabidopsis thaliana phospholipase Dzeta2 in root hydrotropism through the suppression of root gravitropism.
  7. AtPLDzeta2 localizes to the tonoplast and the Nter regulatory domain is sufficient for its sorting. Under phosphate deprivation, AtPLDzeta2 remains located in the tonoplast but its distribution is uneven.
    Title: Phosphate availability affects the tonoplast localization of PLDzeta2, an Arabidopsis thaliana phospholipase D.
  8. pldz2 mutant is defective in the hydrolysis of phospholipids and has a reduced capacity to accumulate galactolipids under limiting Pi conditions
    Title: Phospholipase DZ2 plays an important role in extraplastidic galactolipid biosynthesis and phosphate recycling in Arabidopsis roots.
  9. PLDzeta2 plays a role in regulating root development in response to nutrient limitation.
    Title: Double knockouts of phospholipases Dzeta1 and Dzeta2 in Arabidopsis affect root elongation during phosphate-limited growth but do not affect root hair patterning.
  10. PLDzeta2 and and its product, phosphatidic acid (PA) are required for the normal cycling of PIN2-containing vesicles as well as for function in auxin transport and distribution, and hence auxin responses.
    Title: Arabidopsis PLDzeta2 regulates vesicle trafficking and is required for auxin response.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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General gene information

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NM_111436.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase D activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase D activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to nitrogen starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to phosphate starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within galactolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to auxin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
phospholipase D P2
NP_187214.2
  • phospholipase D P2 (PLDP2); FUNCTIONS IN: phospholipase D activity; INVOLVED IN: in 7 processes; LOCATED IN: vacuole; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Phospholipase D, eukaryota (InterPro:IPR016555), Phospholipase D (InterPro:IPR015679), Phospholipase D/Transphosphatidylase (InterPro:IPR001736), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: phospholipase D P1 (TAIR:AT3G16785.1); Has 2813 Blast hits to 1615 proteins in 467 species: Archae - 4; Bacteria - 808; Metazoa - 511; Fungi - 591; Plants - 736; Viruses - 0; Other Eukaryotes - 163 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    1635194..1640357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111436.6 → NP_187214.2  phospholipase D P2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187214.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A3KH17, Q7XZQ3, Q9M9W8
    UniProtKB/TrEMBL
    A0A178VFZ7
    Conserved Domains (5) summary
    cd06895
    Location:42 → 205
    PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
    cd09138
    Location:365 → 510
    PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    cd09141
    Location:707 → 891
    PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
    PLN02866
    Location:39 → 1046
    PLN02866; phospholipase D
    cd01254
    Location:193 → 341
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M9W8.2

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