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IMPA-1 importin alpha isoform 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819857, updated on 18-Sep-2024

Summary

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Official Symbol
IMPA-1
Official Full Name
importin alpha isoform 1
Primary source
TAIR:AT3G06720
Locus tag
AT3G06720
See related
Araport:AT3G06720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AIMP ALPHA; AT-IMP; ATKAP ALPHA; IMPA1; IMPORTIN ALPHA; importin alpha isoform 1; IMPORTIN ALPHA ISOFORM 1
Summary
Encodes importin alpha involved in nuclear import. Protein interacts with Agrobacterium proteins VirD2 and VirE2. Is not individually essential for Agrobacterium-mediated root transformation, but when overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
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Genomic context

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See IMPA-1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Sequence:
Chromosome: 3; NC_003074.8 (2120324..2124166)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ribosomal L29e protein family Neighboring gene E3 ubiquitin ligase Neighboring gene Thioredoxin z Neighboring gene GATA transcription factor 15 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The LSD1-type zinc finger motifs of Pisum sativa LSD1 are a novel nuclear localization signal and interact with importin alpha. He S, et al. PLoS One, 2011. PMID 21811563, Free PMC Article
  2. Plant importin alpha binds nuclear localization sequences with high affinity and can mediate nuclear import independent of importin beta. Hübner S, et al. J Biol Chem, 1999 Aug 6. PMID 10428841
  3. Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells. Petrovská B, et al. J Exp Bot, 2013 Nov. PMID 24006426, Free PMC Article
  4. Increasing plant susceptibility to Agrobacterium infection by overexpression of the Arabidopsis nuclear protein VIP1. Tzfira T, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12124400, Free PMC Article
  5. The VirE3 protein of Agrobacterium mimics a host cell function required for plant genetic transformation. Lacroix B, et al. EMBO J, 2005 Jan 26. PMID 15616576, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The LSD1-type zinc finger motifs of PsLSD1 are a novel nuclear localization signal and directly bind to importin alpha.
    Title: The LSD1-type zinc finger motifs of Pisum sativa LSD1 are a novel nuclear localization signal and interact with importin alpha.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_111552.3
NM_180193.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus HDA PubMed 
located_in plant-type cell wall HDA PubMed 

General protein information

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Preferred Names
importin alpha isoform 1
NP_187328.1
  • importin alpha isoform 1 (IMPA-1); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, protein import into nucleus; LOCATED IN: cytosol, nuclear envelope, nucleolus, cell wall; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 2 (TAIR:AT4G16143.2); Has 4061 Blast hits to 2975 proteins in 282 species: Archae - 4; Bacteria - 22; Metazoa - 1539; Fungi - 665; Plants - 1109; Viruses - 0; Other Eukaryotes - 722 (source: NCBI BLink).
NP_850524.1
  • AT-IMP; FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, protein import into nucleus; LOCATED IN: cytosol, nuclear envelope, nucleolus, cell wall; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 2 (TAIR:AT4G16143.2); Has 4059 Blast hits to 2974 proteins in 281 species: Archae - 4; Bacteria - 22; Metazoa - 1537; Fungi - 665; Plants - 1109; Viruses - 0; Other Eukaryotes - 722 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    2120324..2124166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111552.3 → NP_187328.1  importin alpha isoform 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187328.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49599, O81520, Q940R6, Q96321, Q9C841, Q9ZRI5
    UniProtKB/TrEMBL
    A0A178VHS3, A0A5S9XAD6
    Conserved Domains (2) summary
    COG5064
    Location:10 → 530
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:244 → 269
    ARM; armadillo repeat [structural motif]

  2. NM_180193.3 → NP_850524.1  importin alpha isoform 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850524.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49599, O81520, Q940R6, Q96321, Q9C841, Q9ZRI5
    UniProtKB/TrEMBL
    A0A178VHS3, A0A5S9XAD6
    Conserved Domains (2) summary
    COG5064
    Location:10 → 530
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:244 → 269
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96321.2

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