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RGLG1 RING domain ligase1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819911, updated on 18-Sep-2024

Summary

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Official Symbol
RGLG1
Official Full Name
RING domain ligase1
Primary source
TAIR:AT3G01650
Locus tag
AT3G01650
See related
Araport:AT3G01650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F4P13.19; F4P13_19; RING domain ligase1
Summary
Encodes RGLG1 (RING domain ligase 1), a RING domain ubiquitin E3 ligase that negatively regulates the drought stress response by mediating ERF53 transcriptional activity.
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Genomic context

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See RGLG1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Sequence:
Chromosome: 3; NC_003074.8 (241739..245284)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily protein Neighboring gene glucuronokinase G Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene sieve element occlusion protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ABA inhibits myristoylation and induces shuttling of the RGLG1 E3 ligase to promote nuclear degradation of PP2CA. Belda-Palazon B, et al. Plant J, 2019 Jun. PMID 30730075
  2. Post-Transcriptional Coordination of the Arabidopsis Iron Deficiency Response is Partially Dependent on the E3 Ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2). Pan IC, et al. Mol Cell Proteomics, 2015 Oct. PMID 26253232, Free PMC Article
  3. RING finger protein RGLG1 and RGLG2 negatively modulate MAPKKK18 mediated drought stress tolerance in Arabidopsis. Yu J, et al. J Integr Plant Biol, 2021 Mar. PMID 32970364
  4. Ubiquitin Ligases RGLG1 and RGLG5 Regulate Abscisic Acid Signaling by Controlling the Turnover of Phosphatase PP2CA. Wu Q, et al. Plant Cell, 2016 Sep. PMID 27577789, Free PMC Article
  5. Arabidopsis RGLG2, functioning as a RING E3 ligase, interacts with AtERF53 and negatively regulates the plant drought stress response. Cheng MC, et al. Plant Physiol, 2012 Jan. PMID 22095047, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RING finger protein RGLG1 and RGLG2 negatively modulate MAPKKK18 mediated drought stress tolerance in Arabidopsis.
    Title: RING finger protein RGLG1 and RGLG2 negatively modulate MAPKKK18 mediated drought stress tolerance in Arabidopsis.
  2. Post-Transcriptional Coordination of the Arabidopsis Iron Deficiency Response is Partially Dependent on the E3 Ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2
    Title: Post-Transcriptional Coordination of the Arabidopsis Iron Deficiency Response is Partially Dependent on the E3 Ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001337352.1
NM_111031.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within auxin metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cytokinin metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of response to water deprivation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RING domain ligase1
NP_186814.1
  • RING domain ligase1 (RGLG1); FUNCTIONS IN: zinc ion binding; INVOLVED IN: N-terminal protein myristoylation, cytokinin metabolic process, auxin metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase2 (TAIR:AT5G14420.2); Has 24426 Blast hits to 13505 proteins in 916 species: Archae - 24; Bacteria - 3147; Metazoa - 7235; Fungi - 3380; Plants - 4548; Viruses - 743; Other Eukaryotes - 5349 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    241739..245284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111031.4 → NP_186814.1  RING domain ligase1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_186814.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SS90
    UniProtKB/TrEMBL
    A0A178VGS3, A0A5S9X885
    Conserved Domains (2) summary
    cd16729
    Location:445 → 489
    RING-HC_RGLG_plant; RING finger, HC subclass, found in RING domain ligase RGLG1, RGLG2 and similar proteins from plant
    cl00057
    Location:133 → 383
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. NM_001337352.1 → NP_001325948.1  RING domain ligase1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SS90
    UniProtKB/TrEMBL
    A0A178VGS3, A0A5S9X885
    Conserved Domains (2) summary
    cd16729
    Location:445 → 489
    RING-HC_RGLG_plant; RING finger, HC subclass, found in RING domain ligase RGLG1, RGLG2 and similar proteins from plant
    cl00057
    Location:133 → 383
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SS90.1

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