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FRD3 MATE efflux family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819995, updated on 18-Sep-2024

Summary

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Official Symbol
FRD3
Official Full Name
MATE efflux family protein
Primary source
TAIR:AT3G08040
Locus tag
AT3G08040
See related
Araport:AT3G08040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATFRD3; FERRIC REDUCTASE DEFECTIVE 3; MAN1; MANGANESE ACCUMULATOR 1
Summary
Encodes a member of the MATE (multidrug and toxin efflux family), expressed in roots but not shoots. Mutants accumulate excess iron, manganese and zinc, and express root Fe(III) chelatase activity even under iron sufficiency conditions. FRD3 is likely to function in root xylem loading of an iron chelator or other factor necessary for efficient iron uptake out of the xylem or apoplastic space and into leaf cells.
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Genomic context

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See FRD3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Sequence:
Chromosome: 3; NC_003074.8 (2566196..2569700, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RNA binding protein Neighboring gene PHD finger family protein Neighboring gene DNA-directed RNA polymerase subunit beta (Protein of unknown function, DUF642) Neighboring gene delta-latroinsectotoxin-Lt1a protein Neighboring gene myb domain protein 83

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative expression profiling reveals a role of the root apoplast in local phosphate response. Hoehenwarter W, et al. BMC Plant Biol, 2016 Apr 28. PMID 27121119, Free PMC Article
  2. Abscisic acid alleviates iron deficiency by promoting root iron reutilization and transport from root to shoot in Arabidopsis. Lei GJ, et al. Plant Cell Environ, 2014 Apr. PMID 24111973
  3. Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Zn tolerance in Arabidopsis thaliana. Pineau C, et al. PLoS Genet, 2012. PMID 23236296, Free PMC Article
  4. The FRD3 citrate effluxer promotes iron nutrition between symplastically disconnected tissues throughout Arabidopsis development. Roschzttardtz H, et al. Plant Cell, 2011 Jul. PMID 21742986, Free PMC Article
  5. The FRD3-mediated efflux of citrate into the root vasculature is necessary for efficient iron translocation. Durrett TP, et al. Plant Physiol, 2007 May. PMID 17351051, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GCN5 plays a critical role in FRD3-mediated iron homeostasis.
    Title: GENERAL CONTROL NONREPRESSED PROTEIN5-Mediated Histone Acetylation of FERRIC REDUCTASE DEFECTIVE3 Contributes to Iron Homeostasis in Arabidopsis.
  2. Our results suggest that FRD3 works as a multimer and is involved in loading Zn into xylem
    Title: Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Zn tolerance in Arabidopsis thaliana.
  3. Data suggest that FRD3 mediated-citrate release in the apoplastic space represents an important process by which efficient iron nutrition is achieved between adjacent tissues lacking symplastic connections.
    Title: The FRD3 citrate effluxer promotes iron nutrition between symplastically disconnected tissues throughout Arabidopsis development.
  4. FRD3 effluxes citrate into the root vasculature, a process important for the translocation of iron to the leaves.
    Title: The FRD3-mediated efflux of citrate into the root vasculature is necessary for efficient iron translocation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001337758.1
NM_111683.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables citrate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to phosphate starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metal ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
MATE efflux family protein
NP_001319499.1
  • FERRIC REDUCTASE DEFECTIVE 3 (FRD3); CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT1G51340.2); Has 16442 Blast hits to 16241 proteins in 2243 species: Archae - 390; Bacteria - 12800; Metazoa - 108; Fungi - 151; Plants - 401; Viruses - 0; Other Eukaryotes - 2592 (source: NCBI BLink).
NP_187461.1
  • FERRIC REDUCTASE DEFECTIVE 3 (FRD3); FUNCTIONS IN: antiporter activity, transporter activity; INVOLVED IN: cellular iron ion homeostasis; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT1G51340.2); Has 16442 Blast hits to 16241 proteins in 2243 species: Archae - 390; Bacteria - 12800; Metazoa - 108; Fungi - 151; Plants - 401; Viruses - 0; Other Eukaryotes - 2592 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    2566196..2569700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001337758.1 → NP_001319499.1  MATE efflux family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VB30, A0A2H1ZEH4, I2GA74

  2. NM_111683.2 → NP_187461.1  MATE efflux family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187461.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SFB0
    UniProtKB/TrEMBL
    A0A178VB30, I2GA74
    Conserved Domains (2) summary
    cd13136
    Location:55 → 509
    MATE_DinF_like; DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins
    TIGR00797
    Location:55 → 436
    matE; putative efflux protein, MATE family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SFB0.1

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