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SERAT2;2 serine acetyltransferase 2;2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820499, updated on 18-Sep-2024

Summary

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Official Symbol
SERAT2;2
Official Full Name
serine acetyltransferase 2;2
Primary source
TAIR:AT3G13110
Locus tag
AT3G13110
See related
Araport:AT3G13110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATSERAT2;2; SAT-1; SAT-A; SAT-M; SAT3; serine acetyltransferase 2;2; SERINE ACETYLTRANSFERASE 3; SERINE ACETYLTRANSFERASE A; SERINE ACETYLTRANSFERASE-1; SERINE ACETYLTRANSFERASE-MITOCHONDRIAL
Summary
Encodes a mitochondrial serine O-acetyltransferase involved in sulfur assimilation and cysteine biosynthesis. Expressed in the vascular system.
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Genomic context

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See SERAT2;2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
1
Sequence:
Chromosome: 3; NC_003074.8 (4214399..4216302, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene multidrug resistance-associated protein 8 Neighboring gene miscRNA Neighboring gene multidrug resistance-associated protein 7 Neighboring gene Ribosomal protein S10p/S20e family protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial serine acetyltransferase functions as a pacemaker of cysteine synthesis in plant cells. Haas FH, et al. Plant Physiol, 2008 Oct. PMID 18753283, Free PMC Article
  2. Mitochondrial cysteine synthase complex regulates O-acetylserine biosynthesis in plants. Wirtz M, et al. J Biol Chem, 2012 Aug 10. PMID 22730323, Free PMC Article
  3. Allosterically gated enzyme dynamics in the cysteine synthase complex regulate cysteine biosynthesis in Arabidopsis thaliana. Feldman-Salit A, et al. Structure, 2012 Feb 8. PMID 22325778
  4. Use of biomolecular interaction analysis to elucidate the regulatory mechanism of the cysteine synthase complex from Arabidopsis thaliana. Berkowitz O, et al. J Biol Chem, 2002 Aug 23. PMID 12063244
  5. The cysteine synthase complex from plants. Mitochondrial serine acetyltransferase from Arabidopsis thaliana carries a bifunctional domain for catalysis and protein-protein interaction. Wirtz M, et al. Eur J Biochem, 2001 Feb. PMID 11168407

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial SERAT2;2 plays a predominant role in cellular OAS formation.
    Title: Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.
  2. Mitochondrial serine acetyltransferase regulates the production of O-acetylserine in the mitochondria, which affects cysteine synthesis.
    Title: Mitochondrial serine acetyltransferase functions as a pacemaker of cysteine synthesis in plant cells.
  3. From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
    Title: In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_112150.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine O-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine O-acetyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables zinc ion binding HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cysteine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cysteine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine acetyltransferase 2;2
NP_187918.1
  • serine acetyltransferase 2;2 (SERAT2;2); FUNCTIONS IN: zinc ion binding, serine O-acetyltransferase activity; INVOLVED IN: response to cadmium ion, cysteine biosynthetic process; LOCATED IN: mitochondrion; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Hexapeptide transferase, conserved site (InterPro:IPR018357), Serine O-acetyltransferase (InterPro:IPR005881), Trimeric LpxA-like (InterPro:IPR011004), Serine acetyltransferase, N-terminal (InterPro:IPR010493); BEST Arabidopsis thaliana protein match is: serine acetyltransferase 2;1 (TAIR:AT1G55920.1); Has 25521 Blast hits to 25511 proteins in 2666 species: Archae - 387; Bacteria - 19255; Metazoa - 8; Fungi - 225; Plants - 240; Viruses - 18; Other Eukaryotes - 5388 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    4214399..4216302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112150.4 → NP_187918.1  serine acetyltransferase 2;2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187918.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0V7U9, Q0WWV4, Q39218, Q42532, Q43739, Q43740, Q7DLZ8, Q7DM01
    UniProtKB/TrEMBL
    A0A178VHI8, A0A5S9XBN0, A0A654F8B1
    Conserved Domains (1) summary
    PLN02357
    Location:17 → 391
    PLN02357; serine acetyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39218.3

Gene LinkOut

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