EIF4A1 eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: EIF4A1
Official Full Name: eukaryotic translation initiation factor 4A1
Primary source: TAIR:AT3G13920
Locus tag: AT3G13920
See related: Araport:AT3G13920
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: eukaryotic translation initiation factor 4A1; RH4; TIF4A1
Summary: eukaryotic translation initiation factor 4A-1
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See EIF4A1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 6

Sequence:: Chromosome: 3; NC_003074.8 (4592248..4595080, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin-dependent kinase A (CDKA) phosphorylates eukaryotic initiation factor 4A (eIF4A)eIF4A1 and eIF4A2 on a conserved threonine residue (threonine-164) within the RNA-binding motif.
Title: eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation.
EIF4A function is essential for plant growth and development in Arabidopsis.
Title: The RNA helicase, eIF4A-1, is required for ovule development and cell size homeostasis in Arabidopsis.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_001084679.1

Supported by ESTs:

NM_001202956.1

Supported by ESTs:

NM_001338092.1

Supported by ESTs:

NM_001338093.1

Supported by ESTs:

NM_112246.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: eukaryotic translation initiation factor 4A1

NP_001078148.1

eukaryotic translation initiation factor 4A1 (EIF4A1); FUNCTIONS IN: protein binding, ATP-dependent helicase activity, translation initiation factor activity; INVOLVED IN: translational initiation; LOCATED IN: cytosol, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eif4a-2 (TAIR:AT1G54270.1); Has 49587 Blast hits to 48995 proteins in 3133 species: Archae - 779; Bacteria - 27305; Metazoa - 6121; Fungi - 4627; Plants - 2620; Viruses - 17; Other Eukaryotes - 8118 (source: NCBI BLink).

NP_001189885.1

eukaryotic translation initiation factor 4A1 (EIF4A1); CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eif4a-2 (TAIR:AT1G54270.2).

NP_001319547.1

eukaryotic translation initiation factor 4A1 (EIF4A1); FUNCTIONS IN: protein binding, ATP-dependent helicase activity, translation initiation factor activity; INVOLVED IN: response to cadmium ion, translational initiation; LOCATED IN: cytosol, nucleolus, cell wall, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eif4a-2 (TAIR:AT1G54270.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_566469.1

eukaryotic translation initiation factor 4A1 (EIF4A1); FUNCTIONS IN: protein binding, ATP-dependent helicase activity, translation initiation factor activity; INVOLVED IN: response to cadmium ion, translational initiation; LOCATED IN: cytosol, nucleolus, cell wall, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eif4a-2 (TAIR:AT1G54270.1); Has 49714 Blast hits to 49117 proteins in 3142 species: Archae - 779; Bacteria - 27442; Metazoa - 6117; Fungi - 4773; Plants - 2624; Viruses - 17; Other Eukaryotes - 7962 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

4592248..4595080 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112246.4 → NP_566469.1 eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566469.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41376, Q0WWD9, Q546P0, Q8LBZ6, Q8RXF3, Q94CM1

UniProtKB/TrEMBL

A0A178V707, A0A5S9XC50

Conserved Domains (1) summary

PTZ00424
Location:26 → 412

PTZ00424; helicase 45; Provisional
NM_001338092.1 → NP_001319547.1 eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

C0Z2Q9, F4JEL4

Conserved Domains (1) summary

PTZ00424
Location:26 → 393

PTZ00424; helicase 45; Provisional
NM_001338093.1 → NP_001327653.1 eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LSZ7, C0Z2Q9
NM_001084679.1 → NP_001078148.1 eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078148.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XC50, A8MRZ7

Conserved Domains (3) summary

PTZ00424
Location:16 → 402

PTZ00424; helicase 45; Provisional

cd00079
Location:242 → 371

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:31 → 231

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_001202956.1 → NP_001189885.1 eukaryotic translation initiation factor 4A1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189885.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XC50, F4JEL5

Conserved Domains (3) summary

PTZ00424
Location:26 → 407

PTZ00424; helicase 45; Provisional

cd00079
Location:247 → 376

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:41 → 236

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...