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FLU Tetratricopeptide repeat (TPR)-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820628, updated on 18-Sep-2024

Summary

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Official Symbol
FLU
Official Full Name
Tetratricopeptide repeat (TPR)-like superfamily protein
Primary source
TAIR:AT3G14110
Locus tag
AT3G14110
See related
Araport:AT3G14110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
FLUORESCENT IN BLUE LIGHT
Summary
Encodes a novel coiled-coil, TPR domain containing protein that is localized to the chloroplast membrane and is involved in chlorophyll biosynthesis. Mutants accumulate protochlorophyllide, an intermediate in the chlorophyll biosynthesis pathway, in dark and release singlet oxygen in plastids in a controlled and non-invasive manner upon a dark/light shift.
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Genomic context

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See FLU in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (4676118..4677689, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene exocyst subunit exo70 family protein D3 Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene ncRNA Neighboring gene nuclear pore complex protein Neighboring gene Aldolase-type TIM barrel family protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo functional analysis of the structural domains of FLUORESCENT (FLU). Hou Z, et al. Plant J, 2021 Jul. PMID 33901334
  2. A genetic approach towards elucidating the biological activity of different reactive oxygen species in Arabidopsis thaliana. Laloi C, et al. J Exp Bot, 2006. PMID 16720605
  3. FLU: a negative regulator of chlorophyll biosynthesis in Arabidopsis thaliana. Meskauskiene R, et al. Proc Natl Acad Sci U S A, 2001 Oct 23. PMID 11606728, Free PMC Article
  4. The Non-canonical Tetratricopeptide Repeat (TPR) Domain of Fluorescent (FLU) Mediates Complex Formation with Glutamyl-tRNA Reductase. Zhang M, et al. J Biol Chem, 2015 Jul 10. PMID 26037924, Free PMC Article
  5. Enzymatic, but not non-enzymatic, 1O2-mediated peroxidation of polyunsaturated fatty acids forms part of the EXECUTER1-dependent stress response program in the flu mutant of Arabidopsis thaliana. Przybyla D, et al. Plant J, 2008 Apr. PMID 18182022

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vivo functional analysis of the structural domains of FLUORESCENT (FLU).
    Title: In vivo functional analysis of the structural domains of FLUORESCENT (FLU).
  2. a ternary complex composed of the C-terminal tetratricopepetide-repeat domain of FLU, GBP, and GluTR, is reported
    Title: The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex with FLU and GluTR-binding protein.
  3. characterize the FLU-GluTR interaction by solving the crystal structures of the uncomplexed TPR domain of FLU (FLU(TPR)) at 1.45-A resolution and the complex of the dimeric domain of GluTR bound to FLU(TPR) at 2.4-A resolution
    Title: The Non-canonical Tetratricopeptide Repeat (TPR) Domain of Fluorescent (FLU) Mediates Complex Formation with Glutamyl-tRNA Reductase.
  4. FLU links chlorophyll synthesis and the target of feedback control
    Title: FLU, a negative feedback regulator of tetrapyrrole biosynthesis, is physically linked to the final steps of the Mg(++)-branch of this pathway.
  5. The impact of the EXECUTER1 utation and the prevalence of enzymatic or non-enzymatic lipid peroxidation on the modes of singlet oxygen activity in flu mutant A. thaliana is reported.
    Title: Enzymatic, but not non-enzymatic, 1O2-mediated peroxidation of polyunsaturated fatty acids forms part of the EXECUTER1-dependent stress response program in the flu mutant of Arabidopsis thaliana.
  6. Immediately after a dark/light shift of the flu mutant, singlet oxygen is generated within the plastids, activating several stress responses triggered by the Executer1 protein.
    Title: A genetic approach towards elucidating the biological activity of different reactive oxygen species in Arabidopsis thaliana.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001202959.1
NM_112267.4
NM_202581.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chlorophyll biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chlorophyll biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oxylipin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to singlet oxygen IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast thylakoid HDA PubMed 
located_in chloroplast thylakoid membrane HDA PubMed 
located_in cytosol HDA PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Tetratricopeptide repeat (TPR)-like superfamily protein
NP_001189888.1
  • FLUORESCENT IN BLUE LIGHT (FLU); FUNCTIONS IN: binding; INVOLVED IN: chlorophyll biosynthetic process, oxylipin biosynthetic process, response to singlet oxygen; LOCATED IN: chloroplast thylakoid membrane, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026).
NP_566478.1
  • FLUORESCENT IN BLUE LIGHT (FLU); FUNCTIONS IN: binding; INVOLVED IN: chlorophyll biosynthetic process, oxylipin biosynthetic process, response to singlet oxygen; LOCATED IN: chloroplast thylakoid membrane, chloroplast, membrane, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026); Has 863 Blast hits to 502 proteins in 124 species: Archae - 8; Bacteria - 276; Metazoa - 453; Fungi - 0; Plants - 82; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).
NP_974310.1
  • FLUORESCENT IN BLUE LIGHT (FLU); FUNCTIONS IN: binding; INVOLVED IN: chlorophyll biosynthetic process, oxylipin biosynthetic process, response to singlet oxygen; LOCATED IN: chloroplast thylakoid membrane, chloroplast, chloroplast envelope, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    4676118..4677689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112267.4 → NP_566478.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566478.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DI70, Q940U6, Q9LJH7
    UniProtKB/TrEMBL
    A0A178VAG9, A0A5S9XC72
    Conserved Domains (2) summary
    sd00006
    Location:242 → 272
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:244 → 314
    TPR_12; Tetratricopeptide repeat

  2. NM_202581.2 → NP_974310.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974310.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4JFR2
    Conserved Domains (3) summary
    sd00006
    Location:158 → 188
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:160 → 227
    TPR_11; TPR repeat
    pfam13424
    Location:126 → 191
    TPR_12; Tetratricopeptide repeat

  3. NM_001202959.1 → NP_001189888.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189888.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4JFR1
    Conserved Domains (3) summary
    sd00006
    Location:243 → 273
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:245 → 312
    TPR_11; TPR repeat
    pfam13424
    Location:211 → 276
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q940U6.1

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