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RR1 response regulator 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820940, updated on 18-Sep-2024

Summary

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Official Symbol
RR1
Official Full Name
response regulator 1
Primary source
TAIR:AT3G16857
Locus tag
AT3G16857
See related
Araport:AT3G16857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARR1; response regulator 1
Summary
Encodes an Arabidopsis response regulator (ARR) protein that acts in concert with other type-B ARRs in the cytokinin signaling pathway. Also involved in cytokinin-dependent inhibition of hypocotyl elongation and cytokinin-dependent greening and shooting in tissue culture.
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Genomic context

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See RR1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Sequence:
Chromosome: 3; NC_003074.8 (5755714..5759443)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Pectin lyase-like superfamily protein Neighboring gene ncRNA Neighboring gene COBRA-like protein 8 precursor Neighboring gene GATA transcription factor 17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The transcriptional repressor ARR1-SRDX suppresses pleiotropic cytokinin activities in Arabidopsis. Heyl A, et al. Plant Physiol, 2008 Jul. PMID 18502977, Free PMC Article
  2. ARR1 directly activates cytokinin response genes that encode proteins with diverse regulatory functions. Taniguchi M, et al. Plant Cell Physiol, 2007 Feb. PMID 17202182
  3. Cytokinin signaling stabilizes the response activator ARR1. Kurepa J, et al. Plant J, 2014 Apr. PMID 24617630
  4. Low temperature inhibits root growth by reducing auxin accumulation via ARR1/12. Zhu J, et al. Plant Cell Physiol, 2015 Apr. PMID 25552473
  5. A genetic framework for the control of cell division and differentiation in the root meristem. Dello Ioio R, et al. Science, 2008 Nov 28. PMID 19039136

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Type-B Cytokinin Response Regulator ARR1 Inhibits Shoot Regeneration in an ARR12-Dependent Manner in Arabidopsis.
    Title: The Type-B Cytokinin Response Regulator ARR1 Inhibits Shoot Regeneration in an ARR12-Dependent Manner in Arabidopsis.
  2. Authors revealed a new link between auxin and cytokinin signaling involving the interaction between ARR1 and IAA17. ARR1 binds to the IAA17 promoter and promotes its expression, especially at SIM incubation stage, which indirectly represses the expression of WUS and inhibits shoot regeneration.
    Title: The Type-B Cytokinin Response Regulator ARR1 Inhibits Shoot Regeneration in an ARR12-Dependent Manner in Arabidopsis.
  3. ARR1 role in shoot branching.
    Title: Cytokinin Targets Auxin Transport to Promote Shoot Branching.
  4. The expression signals of AG were detected in the initiating carpel primordia and regenerating carpels, and co-localized with those of two Type-B ARABIDOPSIS RESPONSE REGULATORs (ARRs), ARR1 and ARR10.
    Title: Type-B ARRs Control Carpel Regeneration Through Mediating AGAMOUS Expression in Arabidopsis.
  5. Data suggest that shoot removal induces the quantitative and qualitative development of chloroplasts in roots, with cytokinin signaling via RESPONSE REGULATOR (ARR)-ARR1 and ARR12 functioning downstream of wounding signaling to up-regulate genes associated with chloroplast development.
    Title: Shoot Removal Induces Chloroplast Development in Roots via Cytokinin Signaling.
  6. SCR mediates ARR1 transcriptional suppression via the RGA protein.
    Title: A SCARECROW-based regulatory circuit controls Arabidopsis thaliana meristem size from the root endodermis.
  7. The cytokinin module ARABIDOPSIS HISTIDINE KINASE3 (AHK3)/ARABIDOPSIS RESPONSE REGULATOR1 (ARR1)/ARR12 was found to interact with the GR24-dependent reduction in LR development, because mutants in this pathway rendered LR development insensitive to GR24.
    Title: Strigolactones spatially influence lateral root development through the cytokinin signaling network.
  8. An arr1,10,12 triple mutant had more drought tolerance due to enhanced cell membrane integrity, anthocyanin synthesis, abscissic acid hypersensitivity, and reduced stomatal aperture. Dehydration and ABA repressed all 3 genes. RR1 is the most critical.
    Title: Arabidopsis type B cytokinin response regulators ARR1, ARR10, and ARR12 negatively regulate plant responses to drought.
  9. low temperature inhibits root growth by reducing auxin accumulation via ARR1/12.
    Title: Low temperature inhibits root growth by reducing auxin accumulation via ARR1/12.
  10. Cytokinin signaling increases the abundance of ARR1, a ubiquitously expressed type-B response regulators (RRB), by preventing its degradation by the 26S proteasome.
    Title: Cytokinin signaling stabilizes the response activator ARR1.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001338265.1
NM_112561.5
NM_180269.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphorelay response regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axillary shoot meristem initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within callus formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular response to cytokinin stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytokinin-activated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cytokinin-activated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within maintenance of shoot apical meristem identity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within primary root development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of anthocyanin metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of chlorophyll biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cytokinin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytokinin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of root meristem growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of root meristem growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of seed growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cytokinin IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to cytokinin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within shoot system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
response regulator 1
NP_566561.2
  • response regulator 1 (RR1); CONTAINS InterPro DOMAIN/s: Response regulator, plant B-type (InterPro:IPR017053), Myb-like DNA-binding domain, SHAQKYF class (InterPro:IPR006447), CheY-like (InterPro:IPR011006), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: response regulator 2 (TAIR:AT4G16110.1); Has 98862 Blast hits to 97820 proteins in 3027 species: Archae - 653; Bacteria - 87858; Metazoa - 53; Fungi - 404; Plants - 2787; Viruses - 5; Other Eukaryotes - 7102 (source: NCBI BLink).
NP_850600.2
  • response regulator 1 (RR1); CONTAINS InterPro DOMAIN/s: Response regulator, plant B-type (InterPro:IPR017053), Myb-like DNA-binding domain, SHAQKYF class (InterPro:IPR006447), CheY-like (InterPro:IPR011006), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Signal transduction response regulator, receiver domain (InterPro:IPR001789), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: response regulator 2 (TAIR:AT4G16110.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    5755714..5759443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180269.3 → NP_850600.2  response regulator 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850600.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VKJ9, A0A7G2ELB6
    Conserved Domains (2) summary
    TIGR01557
    Location:237 → 290
    myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class
    cd17584
    Location:39 → 153
    REC_typeB_ARR-like; phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains

  2. NM_112561.5 → NP_566561.2  response regulator 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566561.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFS4, Q940D0, Q9LIB7, Q9ZWK0
    UniProtKB/TrEMBL
    A0A654F7X2, A0A7G2ELB6, Q67YH9
    Conserved Domains (2) summary
    TIGR01557
    Location:237 → 290
    myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class
    cd17584
    Location:39 → 153
    REC_typeB_ARR-like; phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains

  3. NM_001338265.1 → NP_001325499.1  response regulator 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LLF2, A0A7G2ELB6
    Conserved Domains (2) summary
    TIGR01557
    Location:167 → 220
    myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class
    cd17584
    Location:1 → 83
    REC_typeB_ARR-like; phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q940D0.2

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