U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mtLPD2 lipoamide dehydrogenase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820984, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
mtLPD2
Official Full Name
lipoamide dehydrogenase 2
Primary source
TAIR:AT3G17240
Locus tag
AT3G17240
See related
Araport:AT3G17240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
lipoamide dehydrogenase 2; LIPOAMIDE DEHYDROGENASE 2
Summary
lipoamide dehydrogenase precursor
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mtLPD2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
3
Sequence:
Chromosome: 3; NC_003074.8 (5889663..5892332, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene Protein phosphatase 2C family protein Neighboring gene miscRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The metabolic acclimation of Arabidopsis thaliana to arsenate is sensitized by the loss of mitochondrial LIPOAMIDE DEHYDROGENASE2, a key enzyme in oxidative metabolism. Chen W, et al. Plant Cell Environ, 2014 Mar. PMID 23961884
  2. Characterization of two cDNAs encoding mitochondrial lipoamide dehydrogenase from Arabidopsis. Lutziger I, et al. Plant Physiol, 2001 Oct. PMID 11598235, Free PMC Article
  3. Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana. Timm S, et al. Plant Cell, 2015 Jul. PMID 26116608, Free PMC Article
  4. Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Taylor NL, et al. Plant Physiol, 2004 Feb. PMID 14764908, Free PMC Article
  5. Proteomic approach to identify novel mitochondrial proteins in Arabidopsis. Kruft V, et al. Plant Physiol, 2001 Dec. PMID 11743114, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of mtLPD improves photosynthesis and, in turn, biomass accumulation in Arabidopsis. [mtLPD2]
    Title: Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana.
  2. These results indicate that mitochondrial lipoamide dehydrogenase is an important protein for determining the sensitivity of oxidative metabolism to arsenate in Arabidopsis.
    Title: The metabolic acclimation of Arabidopsis thaliana to arsenate is sensitized by the loss of mitochondrial LIPOAMIDE DEHYDROGENASE2, a key enzyme in oxidative metabolism.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_112601.3
NM_112602.2
NM_180674.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding HDA PubMed 
enables cobalt ion binding HDA PubMed 
enables copper ion binding HDA PubMed 
enables dihydrolipoyl dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding HDA PubMed 
Component Evidence Code Pubs
NOT located_in Golgi apparatus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
lipoamide dehydrogenase 2
NP_566570.3
  • lipoamide dehydrogenase 2 (mtLPD2); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity, copper ion binding, cobalt ion binding, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion; LOCATED IN: mitochondrion, chloroplast, mitochondrial respiratory chain complex I, mitochondrial matrix; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327), Mercuric reductase (InterPro:IPR000815); BEST Arabidopsis thaliana protein match is: mitochondrial lipoamide dehydrogenase 1 (TAIR:AT1G48030.2); Has 42827 Blast hits to 42792 proteins in 3281 species: Archae - 1167; Bacteria - 31429; Metazoa - 914; Fungi - 500; Plants - 625; Viruses - 0; Other Eukaryotes - 8192 (source: NCBI BLink).
NP_566571.1
  • lipoamide dehydrogenase 2 (mtLPD2); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity, copper ion binding, cobalt ion binding, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion; LOCATED IN: mitochondrion, chloroplast, mitochondrial respiratory chain complex I, mitochondrial matrix; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999); BEST Arabidopsis thaliana protein match is: mitochondrial lipoamide dehydrogenase 1 (TAIR:AT1G48030.2); Has 17511 Blast hits to 17511 proteins in 2716 species: Archae - 356; Bacteria - 12773; Metazoa - 655; Fungi - 312; Plants - 149; Viruses - 0; Other Eukaryotes - 3266 (source: NCBI BLink).
NP_851005.1
  • lipoamide dehydrogenase 2 (mtLPD2); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity, copper ion binding, cobalt ion binding, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion; LOCATED IN: mitochondrion, chloroplast, mitochondrial respiratory chain complex I, mitochondrial matrix; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327), Mercuric reductase (InterPro:IPR000815); BEST Arabidopsis thaliana protein match is: mitochondrial lipoamide dehydrogenase 1 (TAIR:AT1G48030.2); Has 42670 Blast hits to 42637 proteins in 3263 species: Archae - 1164; Bacteria - 31277; Metazoa - 912; Fungi - 500; Plants - 625; Viruses - 0; Other Eukaryotes - 8192 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    5889663..5892332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180674.4 → NP_851005.1  lipoamide dehydrogenase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851005.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LBH6, Q9M5K2, Q9ZRQ0
    UniProtKB/TrEMBL
    A0A5S9WML4, A0A5S9XEH6, A0A654F9D0
    Conserved Domains (1) summary
    cl39093
    Location:41 → 507
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  2. NM_112601.3 → NP_566570.3  lipoamide dehydrogenase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566570.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LBH6, Q9M5K2, Q9ZRQ0
    UniProtKB/TrEMBL
    A0A5S9WML4, A0A5S9XEH6, A0A654F9D0
    Conserved Domains (1) summary
    cl39093
    Location:41 → 507
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  3. NM_112602.2 → NP_566571.1  lipoamide dehydrogenase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566571.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9M5K2
    Conserved Domains (1) summary
    PRK06467
    Location:41 → 95
    PRK06467; dihydrolipoamide dehydrogenase; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M5K2.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools