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HYH HY5-homolog [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821027, updated on 18-Sep-2024

Summary

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Official Symbol
HYH
Official Full Name
HY5-homolog
Primary source
TAIR:AT3G17609
Locus tag
AT3G17609
See related
Araport:AT3G17609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
HY5-homolog
Summary
Encodes a homolog of HY5 (HYH). Involved in phyB signaling pathway.
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Genomic context

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See HYH in Genome Data Viewer
Location:
chromosome: 3
Exon count:
3
Sequence:
Chromosome: 3; NC_003074.8 (6023844..6024710)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene transcription regulatory protein SNF5, putative (BSH) Neighboring gene indole-3-acetic acid inducible 31 Neighboring gene RHOMBOID-like protein 14 Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene structural constituent of ribosome Neighboring gene ncRNA Neighboring gene cation/H+ exchanger 19

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Opposite root growth phenotypes of hy5 versus hy5 hyh mutants correlate with increased constitutive auxin signaling. Sibout R, et al. PLoS Genet, 2006 Nov 24. PMID 17121469, Free PMC Article
  2. HY5 and HYH are positive regulators of nitrate reductase in seedlings and rosette stage plants. Jonassen EM, et al. Planta, 2008 Feb. PMID 17929051
  3. Dissection of HY5/HYH expression in Arabidopsis reveals a root-autonomous HY5-mediated photomorphogenic pathway. Zhang Y, et al. PLoS One, 2017. PMID 28683099, Free PMC Article
  4. Both HY5 and HYH are necessary regulators for low temperature-induced anthocyanin accumulation in Arabidopsis seedlings. Zhang Y, et al. J Plant Physiol, 2011 Mar 1. PMID 20932601
  5. Gibberellins negatively regulate low temperature-induced anthocyanin accumulation in a HY5/HYH-dependent manner. Zhang Y, et al. Plant Signal Behav, 2011 May. PMID 21636970, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Light controls stamen elongation via cryptochromes, phytochromes and COP1 through HY5 and HYH.
    Title: Light controls stamen elongation via cryptochromes, phytochromes and COP1 through HY5 and HYH.
  2. Our analysis shows that HY5 does have the potential to regulate the STOM promoter in vitro and that HY5 is expressed in both the epidermis and mesophyll. However, analysis of hy5 and hy5 hyh double mutants (HYH; HY5-HOMOLOG), found that they had normal stomatal development under different light conditions and the expression of stomatal developmental genes was not perturbed following light shift experiments.
    Title: HY5 is not integral to light mediated stomatal development in Arabidopsis.
  3. Genetic analyses reveal that RSM1 mediates multiple functions of HY5 in responses of seed germination, post-germination development to ABA and abiotic stresses, and seedling tolerance to salinity. Pull-down and BiFC assays show that RSM1 interacts with HY5/HYH in vitro and in vivo. RSM1 and HY5/HYH may function as a regulatory module in responses to ABA and abiotic stresses.
    Title: RSM1, an Arabidopsis MYB protein, interacts with HY5/HYH to modulate seed germination and seedling development in response to abscisic acid and salinity.
  4. It has been reported that HY5 regulates HYH expression in roots and contributes to root growth under different light conditions.
    Title: Dissection of HY5/HYH expression in Arabidopsis reveals a root-autonomous HY5-mediated photomorphogenic pathway.
  5. light affected TCP2 expression in a wavelength-dependent manner and TCP2 positively regulates mRNA expression of HYH and HY5.
    Title: TCP2 positively regulates HY5/HYH and photomorphogenesis in Arabidopsis.
  6. This study further reveals that MYC2 and GBF1 bind to HYH promoter and inhibit each other through non-DNA binding bHLH-bZIP heterodimers.
    Title: Interaction of MYC2 and GBF1 results in functional antagonism in blue light-mediated Arabidopsis seedling development.
  7. The DNA binding activity of GBF1 is modulated by heterodimeriation with HY5 and HYH.
    Title: Genome-wide DNA binding of GBF1 is modulated by its heterodimerizing protein partners, HY5 and HYH.
  8. BBX24 and BBX25 physically interact with HYH.
    Title: Molecular interactions of BBX24 and BBX25 with HYH, HY5 HOMOLOG, to modulate Arabidopsis seedling development.
  9. Data indicate that the PIF1/PIF3-HY5/HYH transcriptional modules mediate crosstalk between light and ROS signaling and a mechanism by which plants adapt to the light environments.
    Title: Antagonistic basic helix-loop-helix/bZIP transcription factors form transcriptional modules that integrate light and reactive oxygen species signaling in Arabidopsis.
  10. the functional interrelations of GBF1 with HY5 and HYH in Arabidopsis seedling development.
    Title: Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis thaliana.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001035640.3
NM_001084700.2
NM_180273.2
NM_180274.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to UV-B IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
HY5-homolog
NP_001030717.1
  • HY5-homolog (HYH); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), bZIP transcription factor, bZIP-1 (InterPro:IPR011616); BEST Arabidopsis thaliana protein match is: Basic-leucine zipper (bZIP) transcription factor family protein (TAIR:AT5G11260.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001078169.1
  • HY5-homolog (HYH); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), bZIP transcription factor, bZIP-1 (InterPro:IPR011616); BEST Arabidopsis thaliana protein match is: Basic-leucine zipper (bZIP) transcription factor family protein (TAIR:AT5G11260.1); Has 1702 Blast hits to 1702 proteins in 211 species: Archae - 0; Bacteria - 0; Metazoa - 855; Fungi - 256; Plants - 484; Viruses - 0; Other Eukaryotes - 107 (source: NCBI BLink).
NP_850604.1
  • HY5-homolog (HYH); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), bZIP transcription factor, bZIP-1 (InterPro:IPR011616); BEST Arabidopsis thaliana protein match is: Basic-leucine zipper (bZIP) transcription factor family protein (TAIR:AT5G11260.1); Has 1693 Blast hits to 1693 proteins in 216 species: Archae - 0; Bacteria - 0; Metazoa - 863; Fungi - 250; Plants - 465; Viruses - 0; Other Eukaryotes - 115 (source: NCBI BLink).
NP_850605.1
  • HY5-homolog (HYH); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), bZIP transcription factor, bZIP-1 (InterPro:IPR011616); BEST Arabidopsis thaliana protein match is: Basic-leucine zipper (bZIP) transcription factor family protein (TAIR:AT5G11260.1); Has 1704 Blast hits to 1704 proteins in 215 species: Archae - 0; Bacteria - 0; Metazoa - 880; Fungi - 251; Plants - 456; Viruses - 0; Other Eukaryotes - 117 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    6023844..6024710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001035640.3 → NP_001030717.1  HY5-homolog [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030717.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VKI9, Q682B6
    Conserved Domains (1) summary
    cd14704
    Location:53 → 102
    bZIP_HY5-like; Basic leucine zipper (bZIP) domain of Plant Elongated/Long Hypocotyl5 (HY5)-like transcription factors and similar proteins: a DNA-binding and dimerization domain

  2. NM_180274.3 → NP_850605.1  HY5-homolog [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850605.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LB41, Q8W191, Q9LUN6
    UniProtKB/TrEMBL
    A0A178VIU6, A0A5S9XDK3
    Conserved Domains (1) summary
    cd14704
    Location:82 → 131
    bZIP_HY5-like; Basic leucine zipper (bZIP) domain of Plant Elongated/Long Hypocotyl5 (HY5)-like transcription factors and similar proteins: a DNA-binding and dimerization domain

  3. NM_001084700.2 → NP_001078169.1  HY5-homolog [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078169.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VH92, A0A178VKI9, A0A384LPH1, A8MS70
    Conserved Domains (1) summary
    cd14704
    Location:67 → 116
    bZIP_HY5-like; Basic leucine zipper (bZIP) domain of Plant Elongated/Long Hypocotyl5 (HY5)-like transcription factors and similar proteins: a DNA-binding and dimerization domain

  4. NM_180273.2 → NP_850604.1  HY5-homolog [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850604.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VKI9
    Conserved Domains (1) summary
    cd14704
    Location:68 → 117
    bZIP_HY5-like; Basic leucine zipper (bZIP) domain of Plant Elongated/Long Hypocotyl5 (HY5)-like transcription factors and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8W191.1

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