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MS2 methionine synthase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821147, updated on 18-Sep-2024

Summary

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Official Symbol
MS2
Official Full Name
methionine synthase 2
Primary source
TAIR:AT3G03780
Locus tag
AT3G03780
See related
Araport:AT3G03780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMS2; F20H23.19; F20H23_19; methionine synthase 2
Summary
Encodes a cytosolic methionine synthase, involved in methionine regeneration via the activated methyl cycle (or SAM cycle)
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Genomic context

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See MS2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Sequence:
Chromosome: 3; NC_003074.8 (956862..961032)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ankyrin repeat family protein / regulator of chromosome condensation (RCC1) family protein Neighboring gene syntaxin of plants 131 Neighboring gene O-fucosyltransferase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Male Sterile2 encodes a plastid-localized fatty acyl carrier protein reductase required for pollen exine development in Arabidopsis. Chen W, et al. Plant Physiol, 2011 Oct. PMID 21813653, Free PMC Article
  2. METHIONINE SYNTHASE1 Is Involved in Chromatin Silencing by Maintaining DNA and Histone Methylation. Yan X, et al. Plant Physiol, 2019 Sep. PMID 31331996, Free PMC Article
  3. Methionine metabolism in plants: chloroplasts are autonomous for de novo methionine synthesis and can import S-adenosylmethionine from the cytosol. Ravanel S, et al. J Biol Chem, 2004 May 21. PMID 15024005
  4. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article
  5. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MS2-mediated conserved plastidial pathway for the production of fatty alcohols that are essential for pollen wall biosynthesis in Arabidopsis.
    Title: Male Sterile2 encodes a plastid-localized fatty acyl carrier protein reductase required for pollen exine development in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_001125092.1
NM_111249.5
NM_180176.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methionine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast envelope HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
methionine synthase 2
NP_001118564.1
  • methionine synthase 2 (MS2); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: response to salt stress, methionine biosynthetic process; LOCATED IN: cytosol, apoplast, chloroplast, plasma membrane; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, seedling growth; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: Cobalamin-independent synthase family protein (TAIR:AT5G17920.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_187028.1
  • methionine synthase 2 (MS2); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: response to cadmium ion, response to salt stress, methionine biosynthetic process; LOCATED IN: cytosol, apoplast, plasma membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, seedling growth; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: Cobalamin-independent synthase family protein (TAIR:AT5G17920.2); Has 4502 Blast hits to 4490 proteins in 1700 species: Archae - 186; Bacteria - 3282; Metazoa - 14; Fungi - 208; Plants - 251; Viruses - 2; Other Eukaryotes - 559 (source: NCBI BLink).
NP_850507.1
  • methionine synthase 2 (MS2); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: response to cadmium ion, response to salt stress, methionine biosynthetic process; LOCATED IN: cytosol, apoplast, plasma membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, seedling growth; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: Cobalamin-independent synthase family protein (TAIR:AT5G17920.2); Has 4511 Blast hits to 4499 proteins in 1700 species: Archae - 186; Bacteria - 3291; Metazoa - 14; Fungi - 208; Plants - 251; Viruses - 2; Other Eukaryotes - 559 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    956862..961032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180176.4 → NP_850507.1  methionine synthase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850507.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94BN4, Q9SRV5
    UniProtKB/TrEMBL
    A0A178VKB3, A0A5S9X8U3, A0A654F3V2
    Conserved Domains (1) summary
    PLN02475
    Location:1 → 765
    PLN02475; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

  2. NM_111249.5 → NP_187028.1  methionine synthase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187028.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94BN4, Q9SRV5
    UniProtKB/TrEMBL
    A0A178VKB3, A0A5S9X8U3, A0A654F3V2
    Conserved Domains (1) summary
    PLN02475
    Location:1 → 765
    PLN02475; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

  3. NM_001125092.1 → NP_001118564.1  methionine synthase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118564.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94BN4, Q9SRV5
    UniProtKB/TrEMBL
    A0A178VKB3, A0A5S9X8U3, A0A654F3V2
    Conserved Domains (1) summary
    PLN02475
    Location:1 → 765
    PLN02475; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SRV5.1

Gene LinkOut

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