U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RTL2 RNAse THREE-like protein 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821587, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
RTL2
Official Full Name
RNAse THREE-like protein 2
Primary source
TAIR:AT3G20420
Locus tag
AT3G20420
See related
Araport:AT3G20420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATRTL2; RNAse THREE-like protein 2; RNASEIII-LIKE 2
Summary
double-stranded RNA binding / ribonuclease III. Required for 3' external transcribed spacer (ETS) cleavage of the pre-rRNA in vivo. Localizes in the nucleus and cytoplasm.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RTL2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (7119191..7121023, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene calmodulin-domain protein kinase 9 Neighboring gene phosphorylated adapter RNA export-like protein Neighboring gene Alpha amylase family protein Neighboring gene B-cell receptor-associated protein 31-like protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Arabidopsis RNASE THREE LIKE2 Modulates the Expression of Protein-Coding Genes via 24-Nucleotide Small Interfering RNA-Directed DNA Methylation. Elvira-Matelot E, et al. Plant Cell, 2016 Feb. PMID 26764378, Free PMC Article
  2. An Arabidopsis RNase III-like protein, AtRTL2, cleaves double-stranded RNA in vitro. Kiyota E, et al. J Plant Res, 2011 May. PMID 20978817
  3. Characterization of a ribonuclease III-like protein required for cleavage of the pre-rRNA in the 3'ETS in Arabidopsis. Comella P, et al. Nucleic Acids Res, 2008 Mar. PMID 18158302, Free PMC Article
  4. Specific interactions between Dicer-like proteins and HYL1/DRB-family dsRNA-binding proteins in Arabidopsis thaliana. Hiraguri A, et al. Plant Mol Biol, 2005 Jan. PMID 15821876
  5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Changes in 24-nucleotide siRNA levels also affect DNA methylation levels at such loci and inversely correlate with mRNA steady state levels, thus implicating RTL2 in the regulation of protein-coding gene expression.
    Title: Arabidopsis RNASE THREE LIKE2 Modulates the Expression of Protein-Coding Genes via 24-Nucleotide Small Interfering RNA-Directed DNA Methylation.
  2. Arabidopsis thaliana RTL2 increases the amount of small RNA in vivo.
    Title: An Arabidopsis RNase III-like protein, AtRTL2, cleaves double-stranded RNA in vitro.
  3. Results indicate that AtRTL2 may use a dimeric mechanism to cleave double-stranded RNA.
    Title: Characterization of a ribonuclease III-like protein required for cleavage of the pre-rRNA in the 3'ETS in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
NM_112933.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ribonuclease III activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
RNAse THREE-like protein 2
NP_566661.1
  • RNAse THREE-like protein 2 (RTL2); FUNCTIONS IN: double-stranded RNA binding, ribonuclease III activity; INVOLVED IN: RNA processing; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Double-stranded RNA-binding (InterPro:IPR001159), Ribonuclease III (InterPro:IPR000999); BEST Arabidopsis thaliana protein match is: RNAse THREE-like protein 3 (TAIR:AT5G45150.1); Has 7842 Blast hits to 7448 proteins in 2591 species: Archae - 23; Bacteria - 4871; Metazoa - 597; Fungi - 359; Plants - 331; Viruses - 17; Other Eukaryotes - 1644 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    7119191..7121023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112933.3 → NP_566661.1  RNAse THREE-like protein 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566661.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94B67, Q9LTQ0
    UniProtKB/TrEMBL
    A0A7G2EM66
    Conserved Domains (4) summary
    COG0571
    Location:54 → 294
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00048
    Location:313 → 385
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00593
    Location:75 → 226
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam00035
    Location:232 → 292
    dsrm; Double-stranded RNA binding motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LTQ0.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools