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4CL5 4-coumarate:CoA ligase 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821677, updated on 18-Sep-2024

Summary

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Official Symbol
4CL5
Official Full Name
4-coumarate:CoA ligase 5
Primary source
TAIR:AT3G21230
Locus tag
AT3G21230
See related
Araport:AT3G21230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
4-coumarate:CoA ligase 5
Summary
The gene encodes a 4-coumarate coenzyme A ligase being able to use sinapate as substrate. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, 5-OH-ferulic acid, ferulic acid and sinapic acid. At4CL5 was unable to use cinnamic acid as substrate. Knockout of At4CL5 (4cl5) revealed no effect on syringyl lignin content indicating that the activity observed does probably not occur in vivo.
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Genomic context

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See 4CL5 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
5
Sequence:
Chromosome: 3; NC_003074.8 (7448040..7452106, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene proton gradient regulation 7 Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene MAP kinase kinase 5 Neighboring gene 4-coumarate:CoA ligase 2 Neighboring gene multidrug resistance-associated protein 6 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization in vitro and in vivo of the putative multigene 4-coumarate:CoA ligase network in Arabidopsis: syringyl lignin and sinapate/sinapyl alcohol derivative formation. Costa MA, et al. Phytochemistry, 2005 Sep. PMID 16099486
  2. The 4-coumarate:CoA ligase gene family in Arabidopsis thaliana comprises one rare, sinapate-activating and three commonly occurring isoenzymes. Hamberger B, et al. Proc Natl Acad Sci U S A, 2004 Feb 17. PMID 14769935, Free PMC Article
  3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

General gene information

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NM_001338512.1
NM_001338513.1
NM_001338514.1
NM_113018.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 4-coumarate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within phenylpropanoid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
4-coumarate:CoA ligase 5
NP_188760.3
  • 4-coumarate:CoA ligase 5 (4CL5); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 86695 Blast hits to 79061 proteins in 3832 species: Archae - 1152; Bacteria - 55057; Metazoa - 3672; Fungi - 4648; Plants - 2823; Viruses - 1; Other Eukaryotes - 19342 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    7448040..7452106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113018.4 → NP_188760.3  4-coumarate:CoA ligase 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188760.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q84P22, Q8LPN8, Q9LU36
    UniProtKB/TrEMBL
    A0A654F9B2
    Conserved Domains (1) summary
    PLN02246
    Location:20 → 567
    PLN02246; 4-coumarate--CoA ligase

  2. NM_001338512.1 → NP_001326761.1  4-coumarate:CoA ligase 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LQ96, A0A654F9B2

  3. NM_001338513.1 → NP_001326762.1  4-coumarate:CoA ligase 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LQ97, A0A654F9B2

  4. NM_001338514.1 → NP_001326760.1  4-coumarate:CoA ligase 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LQ95
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LU36.1

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