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4CL2 4-coumarate:CoA ligase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821678, updated on 18-Sep-2024

Summary

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Official Symbol
4CL2
Official Full Name
4-coumarate:CoA ligase 2
Primary source
TAIR:AT3G21240
Locus tag
AT3G21240
See related
Araport:AT3G21240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
4-COUMARATE:COA LIGASE; 4-coumarate:CoA ligase 2; AT4CL2
Summary
encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, 5-OH-ferulic acid and cinnamic acid. At4CL2 was unable to use sinapic acid as substrate.
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Genomic context

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See 4CL2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (7454269..7457404, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene MAP kinase kinase 5 Neighboring gene 4-coumarate:CoA ligase 5 Neighboring gene multidrug resistance-associated protein 6 Neighboring gene ncRNA Neighboring gene Glycolipid transfer protein (GLTP) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Four Isoforms of Arabidopsis 4-Coumarate:CoA Ligase Have Overlapping yet Distinct Roles in Phenylpropanoid Metabolism. Li Y, et al. Plant Physiol, 2015 Dec. PMID 26491147, Free PMC Article
  2. Three 4-coumarate:coenzyme A ligases in Arabidopsis thaliana represent two evolutionarily divergent classes in angiosperms. Ehlting J, et al. Plant J, 1999 Jul. PMID 10417722
  3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 4CL1 or 4CL2 is required for normal plant growth.
    Title: Four Isoforms of Arabidopsis 4-Coumarate:CoA Ligase Have Overlapping yet Distinct Roles in Phenylpropanoid Metabolism.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_001338515.1
NM_001338516.1
NM_113019.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 4-coumarate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within phenylpropanoid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to UV IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to fungus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
4-coumarate:CoA ligase 2
NP_188761.1
  • 4-coumarate:CoA ligase 2 (4CL2); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 1 (TAIR:AT1G51680.1); Has 86092 Blast hits to 78635 proteins in 3758 species: Archae - 1209; Bacteria - 54193; Metazoa - 3597; Fungi - 4717; Plants - 2816; Viruses - 1; Other Eukaryotes - 19559 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    7454269..7457404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113019.4 → NP_188761.1  4-coumarate:CoA ligase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188761.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53Z06, Q56ZS8, Q9LU35, Q9S725
    UniProtKB/TrEMBL
    A0A178VMQ7, B1GUZ3, B1GUZ8
    Conserved Domains (2) summary
    cd05904
    Location:32 → 546
    4CL; 4-Coumarate-CoA Ligase (4CL)
    PLN02246
    Location:14 → 553
    PLN02246; 4-coumarate--CoA ligase

  2. NM_001338515.1 → NP_001327049.1  4-coumarate:CoA ligase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VMQ7, A0A1I9LR43, B1GUZ8

  3. NM_001338516.1 → NP_001327048.1  4-coumarate:CoA ligase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VMQ7, A0A1I9LR43, B1GUZ8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9S725.2

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