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ALF5 MATE efflux family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821935, updated on 18-Sep-2024

Summary

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Official Symbol
ALF5
Official Full Name
MATE efflux family protein
Primary source
TAIR:AT3G23560
Locus tag
AT3G23560
See related
Araport:AT3G23560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ABERRANT LATERAL ROOT FORMATION 5
Summary
Member of the multidrug and toxic compound extrusion (MATE) family, protects roots from inhibitory compounds.
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Genomic context

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See ALF5 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Sequence:
Chromosome: 3; NC_003074.8 (8453903..8456708, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Cyclopropane-fatty-acyl-phospholipid synthase Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene MATE efflux family protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ribonucleotide reductase 2A Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis ALF5, a multidrug efflux transporter gene family member, confers resistance to toxins. Diener AC, et al. Plant Cell, 2001 Jul. PMID 11449055, Free PMC Article
  2. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
  3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
  4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001338646.1
NM_113259.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to toxic substance ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
MATE efflux family protein
NP_566730.1
  • ABERRANT LATERAL ROOT FORMATION 5 (ALF5); FUNCTIONS IN: antiporter activity, drug transmembrane transporter activity, transporter activity; INVOLVED IN: response to toxin; LOCATED IN: membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT3G23550.1); Has 11709 Blast hits to 11651 proteins in 2060 species: Archae - 284; Bacteria - 8224; Metazoa - 146; Fungi - 324; Plants - 1351; Viruses - 0; Other Eukaryotes - 1380 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    8453903..8456708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113259.4 → NP_566730.1  MATE efflux family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566730.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LUH2
    UniProtKB/TrEMBL
    A0A5S9XF04
    Conserved Domains (2) summary
    COG0534
    Location:46 → 475
    NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
    cd13132
    Location:39 → 471
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

  2. NM_001338646.1 → NP_001327615.1  MATE efflux family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LSV7, A0A5S9XF04
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LUH2.1

Gene LinkOut

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