CYP71 cyclophilin71 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CYP71
Official Full Name: cyclophilin71
Primary source: TAIR:AT3G44600
Locus tag: AT3G44600
See related: Araport:AT3G44600
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtCYP71; cyclophilin 71; cyclophilin71
Summary: Cyclophilin71 is a WD40 domain cyclophilin, which functions in gene repression, organogenesis and meristem development. CYP71 physically interacts with histone H3.
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Genomic context

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See CYP71 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 13

Sequence:: Chromosome: 3; NC_003074.8 (16164935..16169304, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peptidyl-prolyl isomerase Cyclophilin71 promotes SERRATE phase separation and miRNA processing in Arabidopsis.
Title: Peptidyl-prolyl isomerase Cyclophilin71 promotes SERRATE phase separation and miRNA processing in Arabidopsis.
CYP71 physically interacts with FAS1 and LHP1 to modulate their distribution on chromatin.
Title: The cyclophilin AtCYP71 interacts with CAF-1 and LHP1 and functions in multiple chromatin remodeling processes.
A WD40 domain cyclophilin, CYCLOPHILIN71 (CYP71), which functions in gene repression and organogenesis in Arabidopsis thaliana, is identified.[CYP71]
Title: A WD40 domain cyclophilin interacts with histone H3 and functions in gene repression and organogenesis in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_114328.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within carpel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf shaping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf vascular tissue pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meristem structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression, epigenetic	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of root meristem growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sepal formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stamen development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: cyclophilin71

NP_190046.2

cyclophilin71 (CYP71); CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT2G36130.1); Has 19122 Blast hits to 18688 proteins in 2726 species: Archae - 110; Bacteria - 7959; Metazoa - 3135; Fungi - 1772; Plants - 1406; Viruses - 0; Other Eukaryotes - 4740 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

16164935..16169304 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_114328.4 → NP_190046.2 cyclophilin71 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190046.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8W4D0, Q9LXM7

UniProtKB/TrEMBL

A0A178VKK0, A0A5S9XHS4

Conserved Domains (4) summary

COG2319
Location:69 → 287

WD40; WD40 repeat [General function prediction only]

cd01927
Location:479 → 626

cyclophilin_WD40; cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. ...

sd00039
Location:73 → 111

7WD40; WD40 repeat [structural motif]

cl02567
Location:68 → 286

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...