HSP93-III Clp ATPase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HSP93-III
Official Full Name: Clp ATPase
Primary source: TAIR:AT3G48870
Locus tag: AT3G48870
See related: Araport:AT3G48870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCLPC; ATHSP93-III; ClpC2
Summary: Encodes a nuclear encoded protein with similarity to Clpa regulatory subunit of CLP protease complex. The protein is localized to the chloroplast stroma. May function redundantly with TIC complex in chloroplast protein import.
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Genomic context

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See HSP93-III in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 10

Sequence:: Chromosome: 3; NC_003074.8 (18122118..18126742, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutant noxy8 exposes functional specificities between the chloroplast chaperones CLPC1 and CLPC2 in the response to organelle stress and plant defence.
Title: Mutant noxy8 exposes functional specificities between the chloroplast chaperones CLPC1 and CLPC2 in the response to organelle stress and plant defence.
AtClpS1 allows for high-affinity binding to classical N-degrons of the bacterial N-end rule.
Title: A Gatekeeper Residue of ClpS1 from Arabidopsis thaliana Chloroplasts Determines its Affinity Towards Substrates of the Bacterial N-End Rule.
the proteolytic activity of Clp protease counteracts GBP binding to assure the appropriate content of GluTR and the adequate amino levulinic acid synthesis for chlorophyll and heme in higher plants.
Title: Posttranslational Control of ALA Synthesis Includes GluTR Degradation by Clp Protease and Stabilization by GluTR-Binding Protein.
Both AtClpC2 and AtClpD interacted with the transit peptides when they were located at the N-terminal position of a protein, but not when they were allocated to the C-terminal end or at the interior of a polypeptide. [ClpC2]
Title: Chloroplastic Hsp100 chaperones ClpC2 and ClpD interact in vitro with a transit peptide only when it is located at the N-terminus of a protein.
The association of Hsp93 with the inner envelope membrane through its amino-terminal domain is important for the functions of Hsp93 in vivo.[Hsp93]
Title: The amino-terminal domain of chloroplast Hsp93 is important for its membrane association and functions in vivo.
Data show that ClpS1 (AT1G68660) interacts with plastid ClpC1 (AT5G50920), ClpC2 (AT3G48870), but not with ClpT1 (AT4G25370) or ClpT2 (AT4G12060).
Title: ClpS1 is a conserved substrate selector for the chloroplast Clp protease system in Arabidopsis.
The interaction of Tic110, Tic40 and Hsp93 in A. thaliana chloroplast protein transport is described. [Hsp93]
Title: In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203106.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within protein import into chloroplast stroma	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plastid	HDA more info	PubMed
located_in plastid stroma	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Clp ATPase

NP_001190035.1

HSP93-III; FUNCTIONS IN: in 6 functions; INVOLVED IN: protein import into chloroplast stroma, chloroplast organization; LOCATED IN: mitochondrion, chloroplast, chloroplast stroma, Tic complex; EXPRESSED IN: guard cell; EXPRESSED DURING: seed development stages; CONTAINS InterPro DOMAIN/s: Clp ATPase, C-terminal (InterPro:IPR019489), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-2 (InterPro:IPR013093), ATPase, AAA+ type, core (InterPro:IPR003593), Chaperonin clpA/B (InterPro:IPR001270), Chaperonin ClpA/B, conserved site (InterPro:IPR018368), Clp, N-terminal (InterPro:IPR004176), UvrB/UvrC protein (InterPro:IPR001943); BEST Arabidopsis thaliana protein match is: CLPC homologue 1 (TAIR:AT5G50920.1).

NP_566912.2

HSP93-III; FUNCTIONS IN: in 6 functions; INVOLVED IN: protein import into chloroplast stroma, chloroplast organization; LOCATED IN: in 7 components; EXPRESSED IN: guard cell, leaf; EXPRESSED DURING: seed development stages; CONTAINS InterPro DOMAIN/s: Clp ATPase, C-terminal (InterPro:IPR019489), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-2 (InterPro:IPR013093), ATPase, AAA+ type, core (InterPro:IPR003593), Chaperonin clpA/B (InterPro:IPR001270), Chaperonin ClpA/B, conserved site (InterPro:IPR018368), UvrB/UvrC protein (InterPro:IPR001943), Clp, N-terminal (InterPro:IPR004176); BEST Arabidopsis thaliana protein match is: CLPC homologue 1 (TAIR:AT5G50920.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

18122118..18126742 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001339385.1 → NP_001325472.1 Clp ATPase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1I9LLC3, Q93ZM4, Q9M2Z6, Q9SXJ7

UniProtKB/TrEMBL

A0A178VA06, A0A5S9XJ62, A0A654FG01

Conserved Domains (1) summary

CHL00095
Location:114 → 929

clpC; Clp protease ATP binding subunit
NM_114746.5 → NP_566912.2 Clp ATPase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566912.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1I9LLC3, Q93ZM4, Q9M2Z6, Q9SXJ7

UniProtKB/TrEMBL

A0A178VA06, A0A5S9XJ62, A0A654FG01

Conserved Domains (1) summary

CHL00095
Location:114 → 929

clpC; Clp protease ATP binding subunit
NM_001339386.1 → NP_001325473.1 Clp ATPase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1I9LLC3, Q93ZM4, Q9M2Z6, Q9SXJ7

UniProtKB/TrEMBL

A0A178VA06, A0A5S9XJ62, A0A654FG01

Conserved Domains (1) summary

CHL00095
Location:114 → 929

clpC; Clp protease ATP binding subunit
NM_001203106.2 → NP_001190035.1 Clp ATPase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190035.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2EVS6, F4JF64

Conserved Domains (6) summary

cd00009
Location:267 → 419

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

CHL00095
Location:83 → 898

clpC; Clp protease ATP binding subunit

pfam02151
Location:501 → 536

UVR; UvrB/uvrC motif

pfam02861
Location:98 → 150

Clp_N; Clp amino terminal domain, pathogenicity island component

pfam07724
Location:628 → 800

AAA_2; AAA domain (Cdc48 subfamily)

pfam10431
Location:807 → 887

ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein